ArticleInternational journal of nanomedicine2013
Synergistic action of cinnamaldehyde with silver nanoparticles against spore-forming bacteria: a case for judicious use of silver nanoparticles for antibacterial applications.
Article in International journal of nanomedicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Active Polymers Containing Silver Nanoparticles Combined With Formulations Based on Essential Oils: Quality Effect on Cereals and Dairy Products.Journal of food science · 2026Article
- Trans-Cinnamaldehyde-Driven Silver Nanoparticles: Dual Role in Targeting Biofilm Disruption and Control of Biofilm‑Forming Pathogens via Impairing Ferrous Ion Uptake.Nanotechnology, science and applications · 2025Article
- Synergistic Antibacterial Properties of Silver Nanoparticles and Its Reducing Agent from Cinnamon Bark Extract.Bioengineering (Basel, Switzerland) · 2024Article
- Biogenic silver nanoparticles and cinnamaldehyde as an effective sanitizer for fresh sweet grape tomatoes.Journal of food science and technology · 2023Article
- Antimicrobial Peptide Synergies for Fighting Infectious Diseases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Article
- Essential Oils Encapsulated in Zeolite Structures as Delivery Systems (EODS): An Overview.Molecules (Basel, Switzerland) · 2022Review
- Design strategies for adhesive hydrogels with natural antibacterial agents as wound dressings: Status and trends.Materials today. Bio · 2022Review
- Nanoparticles-Attractive Carriers of Antimicrobial Essential Oils.Antibiotics (Basel, Switzerland) · 2022Review
- Biogenic Silver Nanoparticles Strategically Combined WithFrontiers in microbiology · 2022Article
- Antimicrobial and antibiofilm potentials of cinnamon oil and silver nanoparticles against Streptococcus agalactiae isolated from bovine mastitis: new avenues for countering resistance.BMC veterinary research · 2021Article
- Enteropathogenic Potential ofFoods (Basel, Switzerland) · 2020Article
- A review on anti-bacterials to combat resistance: From ancient era of plants and metals to present and future perspectives of green nano technological combinations.Asian journal of pharmaceutical sciences · 2020Review
- Bifunctional nano-AgRSC advances · 2019Article
- New Approach For Simvastatin As An Antibacterial: Synergistic Effect With Bio-Synthesized Silver Nanoparticles Against Multidrug-Resistant Bacteria.International journal of nanomedicine · 2019Article
- A Novel Mathematical Model for Studying Antimicrobial Interactions AgainstFrontiers in microbiology · 2019Article
- Antibacterial Activity of In Situ Prepared Chitosan/Silver Nanoparticles Solution Against Methicillin-Resistant Strains of Staphylococcus aureus.Nanoscale research letters · 2018Article
- Antimicrobial Activity of Some Essential Oils-Present Status and Future Perspectives.Medicines (Basel, Switzerland) · 2017Review
- Ti-GO-Ag nanocomposite: the effect of content level on the antimicrobial activity and cytotoxicity.International journal of nanomedicine · 2017Article
- Nanomaterials for alternative antibacterial therapy.International journal of nanomedicine · 2017Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Silver has long been advocated as an effective antimicrobial. However, toxicity issues with silver have led to limited use of silver in nanoform, especially for food preservation. With the aim of exploring combinatorial options that could increase the antibacterial potency of silver nanoparticles and reduce the effective dosage of silver, we evaluated the extent of synergy that a combination of silver nanoparticles and an essential oil representative (cinnamaldehyde) could offer. A battery of gram-positive and gram-negative bacterial strains was utilized for antibacterial assays, and extents of synergism were calculated from fractional inhibitory concentration indices. The activity of nanoparticles was greatly enhanced when utilized in the presence of cinnamaldehyde. We observed combinatorial effects that were strongly additive against all the bacterial strains tested, and genuine synergy was found against spore forming Bacillus cereus and Clostridium perfringens - bacterial strains associated with release of cytotoxins in contaminated food and known for their persistence. Bacterial kill curve analysis revealed a very fast bactericidal action when a combination of two agents was used. The electron and atomic force microscopy also revealed extensive damage to the bacterial cell envelop in the presence of both agents. We also performed hemolysis assays to investigate and approximate the extent of toxicity exhibited by the two agents, and observed no adverse effect at the concentrations required for synergy. This study shows that safe levels of silver in nanoform in combination with essential oil component cinnamaldehyde can be effectively used for controlling the spore-forming bacterial species.
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