Evidence map›Paper›PMID 24376136›Full record

ArticleAdvanced healthcare materials2014

Facile fabrication of polyanhydride/anesthetic nanoparticles with tunable release kinetics.

Bret D Ulery, Ho-Man Kan, Bryce A Williams, Balaji Narasimhan, Kevin W-H Lo, Lakshmi S Nair, Cato T Laurencin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Safety and Biocompatibility of a Spray-Dried Influenza Microparticle Vaccine in Mice.Regenerative engineering and translational medicine · 2025
    Article
  3. Review
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bret D UleryInstitute for Regenerative Engineering, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA; Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA; Department of Orthopaedic Surgery, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA.
Ho-Man Kan
Bryce A Williams
Balaji Narasimhan
Kevin W-H Lo
Lakshmi S Nair
Cato T Laurencin

Funding

Engineered Regeneration of Bone through a Small Molecule Cyclic Adenosine MonophoR21AR060480 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LAURENCIN, CATO T. · 2011 to 2012
$450k
Enhanced Osteoinduction and Angioinduction via Polymer/CaO2 Bone Tissue EngineeriR21AR062771 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LAURENCIN, CATO T. · 2012 to 2013
$427k
NIAMS NIH HHS R21 AR060480NIAMS NIH HHS R21 AR062771
6 · The paper itself

Abstract

This work illustrates a two-step strategy for the fabrication of polymer/drug nanoparticles. Utilizing solvent/non-solvent precipitation and gaseous basification, composite nanoparticles with 0-100% drug loadings are fabricated. Drug release kinetics are dictated by nanoparticle composition allowing future tuning for therapeutic applications.

Indexed as

AmidesAnestheticsHumansKineticsNanoparticlesPain ManagementParticle SizePolyanhydridesRopivacaineSolubilityWaterAmidesAnestheticsPolyanhydridesRopivacaineWateranestheticsnanoparticlespain managementpolymers

Identifiers

PMID24376136
PMCPMC4053479

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.