Evidence map›Paper›PMID 24375939›Full record

ReviewWiley interdisciplinary reviews. RNA

Translational reprogramming in cellular stress response.

Botao Liu, Shu-Bing Qian

Abstract readReview
In one paragraph

Review in Wiley interdisciplinary reviews. RNA. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 159 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
159citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

159 citing papers in PubMed, 1 synthesis or guideline pooled it, 264 citations in OpenAlex.

  1. Current Practice in Bicistronic IRES Reporter Use: A Systematic Review.International journal of molecular sciences · 2021
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99 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Botao LiuGraduate Field of Genetics, Genomics, and Development, Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA.
Shu-Bing Qian
Cornell University · US

Funding

Engineering Ubiquitin Ligases to Investigate Protein Aggregation and NeurodegenerDP2OD006449 · OD · CORNELL UNIVERSITY · PI QIAN, SHU-BING · 2009 to 2009
$2.3M
Linking Nutrient Signaling and Protein Homeostasis in Mammalian AgingR01AG042400 · NIA · CORNELL UNIVERSITY · PI QIAN, SHU-BING · 2013 to 2017
$1.6M
NIA NIH HHS 1R01AG042400-01A1NIA NIH HHS R01 AG042400NIH HHS 1 DP2 OD006449-01NIH HHS DP2 OD006449
6 · The paper itself

Abstract

Cell survival in changing environments requires appropriate regulation of gene expression, including translational control. Multiple stress signaling pathways converge on several key translation factors, such as eIF4F and eIF2, and rapidly modulate messenger RNA (mRNA) translation at both the initiation and the elongation stages. Repression of global protein synthesis is often accompanied with selective translation of mRNAs encoding proteins that are vital for cell survival and stress recovery. The past decade has seen significant progress in our understanding of translational reprogramming in part due to the development of technologies that allow the dissection of the interplay between mRNA elements and corresponding binding proteins. Recent genome-wide studies using ribosome profiling have revealed unprecedented proteome complexity and flexibility through alternative translation, raising intriguing questions about stress-induced translational reprogramming. Many surprises emerged from these studies, including wide-spread alternative translation initiation, ribosome pausing during elongation, and reversible modification of mRNAs. Elucidation of the regulatory mechanisms underlying translational reprogramming will ultimately lead to the development of novel therapeutic strategies for human diseases.

Indexed as

Gene Expression RegulationProtein BiosynthesisStress, PhysiologicalAnimalsEukaryotic Initiation FactorsHumansModels, MolecularOpen Reading FramesRibosomesRNA, MessengerSignal TransductionEukaryotic Initiation FactorsRNA, Messenger

Identifiers

PMID24375939
PMCPMC3991730
OpenAlexW2124825601

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.