ArticleNeurourology and urodynamics2015
Can the adrenergic system be implicated in the pathophysiology of bladder pain syndrome/interstitial cystitis? A clinical and experimental study.
Article in Neurourology and urodynamics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06204874 (Evaluation of Pulsed Radiofrequency Ablation of the Superior Hypogastric Plexus for Treatment of Bladder Pain Syndrome), which is not on this map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Pulsed Radiofrequency Ablation of the Superior Hypogastric Plexus for Treatment of Bladder Pain Syndrome: A Case Series
Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- A Pilot Study of Functional Brain Magnetic Resonance Imaging in BPS/IC Patients: Evidence of Central Sensitization.Urology research & practice · 2024Article
- Interstitial cystitis-an imbalance of risk and protective factors?Frontiers in pain research (Lausanne, Switzerland) · 2024Review
- Unraveling the complexity of bladder-centric chronic pain by intravesical contrast enhanced MRI.Continence (Amsterdam, Netherlands) · 2023Article
- Review
- Silodosin Improves Pain and Urinary Frequency in Bladder Pain Syndrome/Interstitial Cystitis Patients.Journal of clinical medicine · 2022Article
- Small Fiber Polyneuropathy May Be a Nexus Between Autonomic Nervous System Dysregulation and Pain in Interstitial Cystitis/Bladder Pain Syndrome.Frontiers in pain research (Lausanne, Switzerland) · 2021Review
- Effect of Water Avoidance Stress on serum and urinary NGF levels in rats: diagnostic and therapeutic implications for BPS/IC patients.Scientific reports · 2019Article
- Persistent autonomic dysfunction and bladder sensitivity in primary dysmenorrhea.Scientific reports · 2019Article
- Stress-induced autonomic dysregulation of mitochondrial function in the rat urothelium.Neurourology and urodynamics · 2019Article
- Animal Modelling of Interstitial Cystitis/Bladder Pain Syndrome.International neurourology journal · 2018Review
- Current Pharmacologic Approaches in Painful Bladder Research: An Update.International neurourology journal · 2017Review
- The water avoidance stress induces bladder pain due to a prolonged alpha1A adrenoceptor stimulation.Naunyn-Schmiedeberg's archives of pharmacology · 2017Article
- Sympathetic nervous system and chronic bladder pain: a new tune for an old song.Translational andrology and urology · 2015Review
- From bladder to systemic syndrome: concept and treatment evolution of interstitial cystitis.International journal of women's health · 2015Review
- Effects of the Fourth Ventricle Compression in the Regulation of the Autonomic Nervous System: A Randomized Control Trial.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Role of NLRP3 inflammasome in the development of bladder pain syndrome interstitial cystitis.Therapeutic advances in urologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
aimsTo evaluate sympathetic system activity in bladder pain syndrome/interstitial cystitis (BPS/IC) patients and to investigate if chronic adrenergic stimulation in intact rats induces BPS/IC-like bladder modifications.
methodsClinical study--In BPS/IC patients and aged and body mass index matched volunteers TILT test was undertaken and catecholamines were measured in plasma and 24 hr urine samples. Experimental study--Phenylephrine was injected subcutaneously (14 days) to female Wistar rats. Pain behavior, spinal Fos expression, urinary spotting, number of fecal pellets expelled, frequency of reflex bladder contractions, and urothelial height were analyzed. Urothelium permeability was investigated by trypan blue staining. Immunoreactivity against caspase 3 and bax were studied in the urothelium and against alpha-1-adrenoreceptor and TRPV1 in suburothelial nerves. Mast cell number was determined in the sub-urothelium. In rats with lipopolysaccharide-induced cystitis, urinary catecholamines, and Vesicular Monoamine Transporter 2 (VMAT2) expression in bladder nerves were analyzed.
resultsThe TILT test showed an increase of sympathetic activity. Noradrenaline levels in blood at resting conditions and in 24-hr urine samples were higher in BPS/IC patients. Phenylephrine administration increased visceral pain, spinal Fos expression, bladder reflex activity, urinary spotting and the number of expelled fecal pellets. The mucosa showed urothelial thinning and increased immunoreactivity for caspase 3 and bax. Trypan blue staining was only observed in phenylephrine treated animals. Suburothelial nerves co-expressed alpha1 and TRPV1. Mastocytosis was present in the suburothelium. Cystitis increased sympathetic nerve density and urinary noradrenaline levels.
conclusionsExcessive adrenergic stimulation of the bladder may contribute to the pathophysiological mechanisms of BPS/IC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.