ArticleEnvironmental and molecular mutagenesis2014
Effects of age, sex, and persistent organic pollutants on DNA methylation in children.
Article in Environmental and molecular mutagenesis, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 95 citations in OpenAlex.
- A Systematic Review of Environmental Health Outcomes in Selected American Indian and Alaska Native Populations.Journal of racial and ethnic health disparities · 2020Pooled it
- Environmental Epigenetic Changes, as Risk Factors for the Development of Diseases in Children: A Systematic Review.Annals of global health · 2018Pooled it
- Mapping assays to the key characteristics of carcinogens to support decision-making.Database : the journal of biological databases and curation · 2025Article
- DNA methylation in the association between pesticide exposures and type 2 diabetes.World journal of diabetes · 2025Article
- Depression, Subjective Health, Obesity, and Multimorbidity are Associated with Epigenetic Age Acceleration.Journal of biomedical and life sciences · 2025Article
- Serum levels of per- and polyfluoroalkylated substances and methylation of DNA from peripheral blood.Frontiers in public health · 2025Article
- Update of the risk assessment of polybrominated diphenyl ethers (PBDEs) in food.EFSA journal. European Food Safety Authority · 2024Article
- Epigenetic processes involved in response to pesticide exposure in human populations: a systematic review and meta-analysis.Environmental epigenetics · 2024Review
- Is adiposity related to repeat measures of blood leukocyte DNA methylation across childhood and adolescence?Clinical obesity · 2023Article
- Polybrominated diphenyl ethers in the environment: a wake-up call for concerted action in India.Environmental science and pollution research international · 2021Review
- Association Between Midpregnancy Polyunsaturated Fatty Acid Levels and Offspring Autism Spectrum Disorder in a California Population-Based Case-Control Study.American journal of epidemiology · 2021Article
- Environmental and socio-cultural impacts on global DNA methylation in the indigenous Huichol population of Nayarit, Mexico.Environmental science and pollution research international · 2021Article
- Epigenetic influence of environmentally neurotoxic metals.Neurotoxicology · 2020Review
- Epigenome-wide association study for pesticide (Permethrin and DEET) induced DNA methylation epimutation biomarkers for specific transgenerational disease.Environmental health : a global access science source · 2020Article
- New Insights into Mechanisms of Endocrine-Disrupting Chemicals in Thyroid Diseases: The Epigenetic Way.International journal of environmental research and public health · 2020Review
- Global DNA methylation and cognitive and behavioral outcomes at 4 years of age: A cross-sectional study.Brain and behavior · 2020Article
- DDT exposure during pregnancy and DNA methylation alterations in female offspring in the Child Health and Development Study.Reproductive toxicology (Elmsford, N.Y.) · 2020Article
- Epigenetic Effects of Polybrominated Diphenyl Ethers on Human Health.International journal of environmental research and public health · 2019Review
- Prenatal epigenetics diets play protective roles against environmental pollution.Clinical epigenetics · 2019Review
- Statistical Methodology in Studies of Prenatal Exposure to Mixtures of Endocrine-Disrupting Chemicals: A Review of Existing Approaches and New Alternatives.Environmental health perspectives · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Epigenetic changes such as DNA methylation may be a molecular mechanism through which environmental exposures affect health. Methylation of Alu and long interspersed nucleotide elements (LINE-1) is a well-established measure of DNA methylation often used in epidemiologic studies. Yet, few studies have examined the effects of host factors on LINE-1 and Alu methylation in children. We characterized the relationship of age, sex, and prenatal exposure to persistent organic pollutants (POPs), dichlorodiphenyl trichloroethane (DDT), dichlorodiphenyldichloroethylene (DDE), and polybrominated diphenyl ethers (PBDEs), with DNA methylation in a birth cohort of Mexican-American children participating in the CHAMACOS study. We measured Alu and LINE-1 methylation by pyrosequencing bisulfite-treated DNA isolated from whole blood samples collected from newborns and nine-year old children (n = 358). POPs were measured in maternal serum during late pregnancy. Levels of DNA methylation were lower in nine-year olds compared to newborns and were higher in boys compared to girls. Higher prenatal DDT/E exposure was associated with lower Alu methylation at birth, particularly after adjusting for cell type composition (P = 0.02 for o,p' -DDT). Associations of POPs with LINE-1 methylation were only identified after examining the co-exposure of DDT/E with PBDEs simultaneously. Our data suggest that repeat element methylation can be an informative marker of epigenetic differences by age and sex and that prenatal exposure to POPs may be linked to hypomethylation in fetal blood. Accounting for co-exposure to different types of chemicals and adjusting for blood cell types may increase sensitivity of epigenetic analyses for epidemiological studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.