ArticlePflugers Archiv : European journal of physiology1987
Single glutamate-gated synaptic channels at the crayfish neuromuscular junction. II. Dependence of channel open time on glutamate concentration.
Article in Pflugers Archiv : European journal of physiology, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Depolarization increases the single-channel conductance and the open probability of crayfish glutamate channels.Biophysical journal · 1998Article
- Activation and blockade of mouse muscle nicotinic channels by antibodies directed against the binding site of the acetylcholine receptor.The Journal of physiology · 1996Article
- GABAergic inhibition of crayfish deep extensor abdominal muscle exhibits a steep dose-response relationship and a high degree of cooperativity.Pflugers Archiv : European journal of physiology · 1995Article
- Gating kinetics of the quisqualate-sensitive glutamate receptor of locust muscle studied using agonist concentration jumps and computer simulations.Biophysical journal · 1993Article
- Patch-clamp recordings of spiking and nonspiking interneurons from rabbit olfactory bulb slices: GABA- and other transmitter receptors.Journal of comparative physiology. A, Sensory, neural, and behavioral physiology · 1992Article
- Activation and desensitization of embryonic-like receptor channels in mouse muscle by acetylcholine concentration steps.The Journal of physiology · 1992Article
- Kinetic constants of the acetylcholine (ACh) receptor reaction deduced from the rise in open probability after steps in ACh concentration.Biophysical journal · 1991Article
- Dual activation of a sex pheromone-dependent ion channel from insect olfactory dendrites by protein kinase C activators and cyclic GMP.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Steep concentration dependence and fast desensitization of nicotinic channel currents elicited by acetylcholine pulses, studied in adult vertebrate muscle.Pflugers Archiv : European journal of physiology · 1991Article
- Intraburst kinetic properties of the GABAA receptor main conductance state of mouse spinal cord neurones in culture.The Journal of physiology · 1990Article
- Rapid activation, desensitization, and resensitization of synaptic channels of crayfish muscle after glutamate pulses.Biophysical journal · 1990Article
- Argiopine blocks glutamate-activated single-channel currents on crayfish muscle by two mechanisms.The Journal of physiology · 1989Article
- Kinetic properties of the GABAA receptor main conductance state of mouse spinal cord neurones in culture.The Journal of physiology · 1989Article
- Anomalous voltage dependence of channel blockade at a crustacean glutamate-mediated synapse.The Journal of physiology · 1989Article
- Activation of single ion channels from toad retinal rod inner segments by cyclic GMP: concentration dependence.The Journal of physiology · 1988Article
- Ionic permeabilities of L-glutamate activated, excitatory synaptic channel in crayfish muscle.Pflugers Archiv : European journal of physiology · 1988Article
- Calcium dependent gating of the L-glutamate activated, excitatory synaptic channel on crayfish muscle.Pflugers Archiv : European journal of physiology · 1988Article
- Glutamate receptor channel kinetics: the effect of glutamate concentration.Biophysical journal · 1988Article
- Acetylcholine activates a chloride channel as well as glutamate and GABA.Journal of comparative physiology. A, Sensory, neural, and behavioral physiology · 1988Article
- Single glutamate-gated synaptic channels at the crayfish neuromuscular junction. I. The effect of enzyme treatment.Pflugers Archiv : European journal of physiology · 1987Article
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2 authors.
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Abstract
Single, glutamate activated ionic channel currents were recorded from crayfish muscle in the cell attached mode. Different concentrations of glutamate were present in the patch clamp pipette. Bursts of openings were observed with a concentration dependent number of short gaps per burst. Also the mean burst length was concentration dependent and varied between 0.3 ms (100 microM) and 1.3 ms (20 mM). Even with the highest concentrations of glutamate the channel activations were well separated and the beginning and the end of a burst could be defined. The distributions of open times and of burst lengths could be fitted well with a single exponential component for all studied concentrations of glutamate. The distributions of closed times were composed of two or three exponential components (with possibly more than one channel contributing). The mean burst length was compared with the time constants of decay of synaptic currents (0.8-3.0 ms at 19 degrees C) which were measured either with the same pipette as the single channel currents or with a macro patch technique. An estimation of the glutamate concentration at the receptors during synaptic transmission gave values in the millimolar range. The most simple model of glutamate-receptor interaction contains two binding sites for glutamate but no singly liganded open states. Rate constants were estimated for this model.
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