ArticleApplied and environmental microbiology2014
Identification and upregulation of biosynthetic genes required for accumulation of Mycosporine-2-glycine under salt stress conditions in the halotolerant cyanobacterium Aphanothece halophytica.
Article in Applied and environmental microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 91 citations in OpenAlex.
- Genomic and secondary metabolites of the marine cyanobacterium Capilliphycus salinus ALCB114379.Journal of phycology · 2026Article
- Transcriptomic data sets forMicrobiology resource announcements · 2026Article
- Responses of Biofilm-Forming HalophilicMicroorganisms · 2026Article
- Efficient Production of Shinorine and Mycosporine-Glycine-Alanine inJournal of agricultural and food chemistry · 2025Article
- Exploring Mycosporine-like Amino Acid UV-Absorbing Natural Products for a New Generation of Environmentally Friendly Sunscreens.Marine drugs · 2023Review
- Exploring the Relationship between Biosynthetic Gene Clusters and Constitutive Production of Mycosporine-like Amino Acids in Brazilian Cyanobacteria.Molecules (Basel, Switzerland) · 2023Article
- Global transcriptome analyses and regulatory mechanisms in Halothece sp. PCC 7418 exposed to abiotic stresses.Applied microbiology and biotechnology · 2022Article
- Global transcriptional and circadian regulation in a halotolerant cyanobacterium Halothece sp. PCC7418.Scientific reports · 2022Article
- Genome Mining as an Alternative Way for Screening the Marine Organisms for Their Potential to Produce UV-Absorbing Mycosporine-like Amino Acid.Marine drugs · 2022Review
- Recent advances in the discovery of novel marine natural products and mycosporine-like amino acid UV-absorbing compounds.Applied microbiology and biotechnology · 2021Review
- Mycosporine-Like Amino Acids (MAAs): Biology, Chemistry and Identification Features.Pharmaceuticals (Basel, Switzerland) · 2021Review
- The Effects of Salts and Osmoprotectants on Enzyme Activities of Fructose-1,6-biphosphate Aldolases in a Halotolerant Cyanobacterium,Life (Basel, Switzerland) · 2020Article
- Mycosporine-Like Amino Acids: Making the Foundation for Organic Personalised Sunscreens.Marine drugs · 2019Review
- Natural Products from Cyanobacteria: Focus on Beneficial Activities.Marine drugs · 2019Review
- Antioxidative, Anti-Inflammatory, and Anti-Aging Properties of Mycosporine-Like Amino Acids: Molecular and Cellular Mechanisms in the Protection of Skin-Aging.Marine drugs · 2019Review
- A Method for the Isolation and Characterization of Mycosporine-Like Amino Acids from Cyanobacteria.Methods and protocols · 2018Article
- Mycosporine-Like Amino Acids for Skin Photoprotection.Current medicinal chemistry · 2018Review
- The sedoheptulose 7-phosphate cyclases and their emerging roles in biology and ecology.Natural product reports · 2017Review
- Evolution and Distribution of CACS chemical biology · 2017Article
- Heterologous Production of Cyanobacterial Mycosporine-Like Amino Acids Mycosporine-Ornithine and Mycosporine-Lysine in Escherichia coli.Applied and environmental microbiology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mycosporine-like amino acids (MAAs) are valuable molecules that are the basis for important photoprotective constituents. Here we report molecular analysis of mycosporine-like amino acid biosynthetic genes from the halotolerant cyanobacterium Aphanothece halophytica, which can survive at high salinity and alkaline pH. This extremophile was found to have a unique MAA core (4-deoxygadusol)-synthesizing gene separated from three other genes. In vivo analysis showed accumulation of the mycosporine-2-glycine but not shinorine or mycosporine-glycine. Mycosporine-2-glycine accumulation was stimulated more under the stress condition of high salinity than UV-B radiation. The Aphanothece MAA biosynthetic genes also manifested a strong transcript level response to salt stress. Furthermore, the transformed Escherichia coli and Synechococcus strains expressing four putative Aphanothece MAA genes under the control of a native promoter were found to be capable of synthesizing mycosporine-2-glycine. The accumulation level of mycosporine-2-glycine was again higher under the high-salinity condition. In the transformed E. coli cells, its level was approximately 85.2 ± 0.7 μmol/g (dry weight). Successful production of a large amount of mycosporine in these cells provides a new opportunity in the search for an alternative natural sunscreen compound source.
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