ArticlePituitary2015
Primary (autoimmune) hypophysitis: a single centre experience.
Article in Pituitary, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Outcomes of Initial Management Strategies in Patients With Autoimmune Lymphocytic Hypophysitis: A Systematic Review and Meta-analysis.The Journal of clinical endocrinology and metabolism · 2022Pooled it
- Pituitary involvement in ANCA-associated vasculitis: a retrospective single-center experience and literature review.Journal of endocrinological investigation · 2026Article
- An update on hypophysitis.Nature reviews. Endocrinology · 2026Review
- The Diagnostic Challenge of Hypophysitis vs. Non-Functioning Pituitary Macroadenomas: An Updated Review and Comparative Analysis of Distinguishing Criteria.Diagnostics (Basel, Switzerland) · 2026Review
- Clinical and radiological insights into secondary hypophysitis: A single-center experience with a focus on tuberculosis.Endocrine · 2025Article
- Effects of glucocorticoid replacement therapy in patients with pituitary disease: A new perspective for personalized replacement therapy.Reviews in endocrine & metabolic disorders · 2024Review
- Complete remission after glucocorticoid therapy in a patient with primary hypophysitis.Endocrinology, diabetes & metabolism case reports · 2024Article
- Coronavirus as a trigger of lymphocytic hypophysitis in an adolescent girl: An exceptional case report.International journal of surgery case reports · 2024Article
- [Differential diagnosis and tactics of managing a patient with primary hypophysitis on the example of a clinical case].Problemy endokrinologii · 2024Article
- A novel approach to hypophysitis: outcomes using non-glucocorticoid immunosuppressive therapy.European journal of endocrinology · 2023Review
- Central diabetes insipidus with anti-rabphilin-3A antibody positivity causing hypovolemic shock after resection of tumorous lesions in the pelvic cavity.CEN case reports · 2023Article
- A Case of Lymphocytic Infundibulo-neurohypophysitis Exhibiting Spontaneous Regression.JCEM case reports · 2023Article
- Clinical presentation and magnetic resonance imaging characteristics of lymphocytic hypophysitis: a systematic review with meta-analysis.Archives of medical science : AMS · 2023Review
- IgG4-related hypophysitis: a retrospective cohort study.Acta neurochirurgica · 2022Article
- Autoantibody reactivity profile of primary autoimmune hypophysitis patients: preliminary results.Endocrine · 2022Article
- Early Detection of Immune-Mediated Hypophysitis With Use of Checkpoint Inhibitor Immunotherapy.Cureus · 2022Article
- Full recovery from chronic headache and hypopituitarism caused by lymphocytic hypophysitis: A case report.World journal of clinical cases · 2022Article
- Hypophysitis, the Growing Spectrum of a Rare Pituitary Disease.The Journal of clinical endocrinology and metabolism · 2022Review
- Molecular and Genetic Immune Biomarkers of Primary and Immune-Therapy Induced Hypophysitis: From Laboratories to the Clinical Practice.Journal of personalized medicine · 2021Review
- Complete Resolution of the Pituitary Mass Lesion and Improvement of Pituitary Function with Corticosteroid in Autoimmune Hypophysitis: A Case Report.Ethiopian journal of health sciences · 2021Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAutoimmune hypophysitis (AH) is a rare autoimmune inflammatory disorder of pituitary gland.
objectiveTo analyse clinical, hormonal, radiological features and management outcomes of AH.
designRetrospective analysis of patients with primary hypophysitis (where secondary causes of hypophysitis were ruled out) was carried out from 2006 to 2012. AH emerged as the most plausible aetiology and the diagnosis of exclusion.
resultsTwenty-four patients with AH (21 females and 3 males) were evaluated. They presented with symptoms of expanding sellar mass (83.3%), symptoms of anterior pituitary hormone deficiencies (58.3%), and diabetes insipidus (16.7%). The anterior pituitary hormonal axes affected were cortisol (75%), thyroid (58.33%) and gonadotropin (50%). All had sellar mass on magnetic resonance imaging, which was symmetrical (91.7%) and homogenously enhancing (91.7%). Stalk thickening, suprasellar extension, loss of posterior pituitary hyperintensity and parasellar T2 dark sign were seen in 87.5, 87.5, 71.5, and 50% respectively. In addition to hormone replacement, five (20.83%) patients underwent trans-sphenoidal surgery, fifteen (62.5%) were watchfully monitored, while four cases (16.67%) received steroid pulse therapy. On follow up imaging, the sellar mass regressed in all, while, stalk thickening was persistent in 13/19 (68.4%) non-operated patients at median follow up of 1 year. Pituitary hormone axis recovery was seen in 10 (41.67%) and was seen in cortisol 10/18 (55.5%) followed by gonadotropin 5/12 (41.67%) axis.
conclusionCharacteristic radiology helps in diagnosis of AH even without tissue diagnosis. Non-operative treatment is the preferred treatment modality. Steroid pulse therapy potentially improves pituitary axis recovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.