ArticleJournal of neurophysiology2014
Caffeine accelerates recovery from general anesthesia.
Article in Journal of neurophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05655806 (Effect of Aminophylline Bolus Versus Infusion on Recovery Time in Patients Undergoing Lumbar Spine Surgery), which is not on this map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Aminophylline Bolus Versus Infusion on Recovery Time in Patients Undergoing Lumbar Spine Surgery: Double Blind Randomized Controlled Trial
Who cites it
31 citing papers in PubMed, 54 citations in OpenAlex.
- Caffeine Accelerates Emergence from Isoflurane Anesthesia in Humans: A Randomized, Double-blind, Crossover Study.Anesthesiology · 2018Trial
- Current and Developing Approaches for Facilitating Emergence from General Anesthesia.Anesthesiology · 2025Review
- Effect of Anesthesia and Diurnal Variation on Chronic Vagus Nerve Activity in Rats.Journal of neuroscience research · 2025Article
- Antagonism of propofol anesthesia by alkyl-fluorobenzene derivatives.Scientific reports · 2024Article
- Restoring consciousness with pharmacologic therapy: Mechanisms, targets, and future directions.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Review
- Exogenous Ketone Supplement Administration Abrogated Isoflurane-Anesthesia-Induced Increase in Blood Glucose Level in Female WAG/Rij Rats.Nutrients · 2024Article
- Time to Wake Up! The Ongoing Search for General Anesthetic Reversal Agents.Anesthesiology · 2024Article
- Antagonism of Propofol Anesthesia by Alkyl-fluorobenzene Derivatives.Research square · 2024Article
- Ketone supplementation abolished isoflurane anesthesia-induced elevation in blood glucose level and increased recovery time from anesthesia in Wistar Albino Glaxo Rijswijk rats.BMC anesthesiology · 2023Article
- Rapid emergence from dexmedetomidine sedation in Sprague Dawley rats by repurposing an αBMC anesthesiology · 2023Article
- Caffeine Use in the Anesthetic Management of a Patient With Congenital Central Hypoventilation.Cureus · 2022Article
- Historical and Modern Evidence for the Role of Reward Circuitry in Emergence.Anesthesiology · 2022Review
- Use of therapeutic caffeine in acute care postoperative and critical care settings: a scoping review.BMC anesthesiology · 2021Article
- Return of the Righting Reflex Does Not Portend Recovery of Cognitive Function in Anesthetized Rats.Frontiers in systems neuroscience · 2021Article
- D-Amphetamine Rapidly Reverses Dexmedetomidine-Induced Unconsciousness in Rats.Frontiers in pharmacology · 2021Article
- The Association Between Coffee Consumption and Local Anesthesia Failure: Social Beliefs and Scientific Evidence.Cureus · 2020Article
- Delayed Emergence from Anesthesia: What We Know and How We Act.Local and regional anesthesia · 2020Review
- Caffeine reverses the unconsciousness produced by light anesthesia in the continued presence of isoflurane in rats.PloS one · 2020Article
- The effect of caffeine on cerebral metabolism during alpha-chloralose anesthesia differs from isoflurane anesthesia in the rat brain.Psychopharmacology · 2019Article
- Escape From Oblivion: Neural Mechanisms of Emergence From General Anesthesia.Anesthesia and analgesia · 2019Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
General anesthetics inhibit neurotransmitter release from both neurons and secretory cells. If inhibition of neurotransmitter release is part of an anesthetic mechanism of action, then drugs that facilitate neurotransmitter release may aid in reversing general anesthesia. Drugs that elevate intracellular cAMP levels are known to facilitate neurotransmitter release. Three cAMP elevating drugs (forskolin, theophylline, and caffeine) were tested; all three drugs reversed the inhibition of neurotransmitter release produced by isoflurane in PC12 cells in vitro. The drugs were tested in isoflurane-anesthetized rats. Animals were injected with either saline or saline containing drug. All three drugs dramatically accelerated recovery from isoflurane anesthesia, but caffeine was most effective. None of the drugs, at the concentrations tested, had significant effects on breathing rates, O2 saturation, heart rate, or blood pressure in anesthetized animals. Caffeine alone was tested on propofol-anesthetized rats where it dramatically accelerated recovery from anesthesia. The ability of caffeine to accelerate recovery from anesthesia for different chemical classes of anesthetics, isoflurane and propofol, opens the possibility that it will do so for all commonly used general anesthetics, although additional studies will be required to determine whether this is in fact the case. Because anesthesia in rodents is thought to be similar to that in humans, these results suggest that caffeine might allow for rapid and uniform emergence from general anesthesia in human patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.