ArticleThe Journal of comparative neurology2014
Coexpression of three opsins in cone photoreceptors of the salamander Ambystoma tigrinum.
Article in The Journal of comparative neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Physiological Postnatal Neurogenesis, Development, and Maturation in the Regenerable Retina.The Journal of comparative neurology · 2026Article
- Accessible and robust machine learning approaches to improve the opsin genotype-phenotype map.Molecular biology and evolution · 2026Article
- Caecilians maintain a functional long-wavelength-sensitive cone opsin gene despite signatures of relaxed selection and more than 200 million years of fossoriality.Evolution; international journal of organic evolution · 2025Article
- Exceptional Visual-Opsin Coexpression and Phenotypic Diversity in Outer-Retinal Photoreceptors of Caenophidian Snakes.The Journal of comparative neurology · 2025Article
- Caecilians maintain a functional long-wavelength-sensitive cone opsin gene despite signatures of relaxed selection and more than 200 million years of fossoriality.bioRxiv : the preprint server for biology · 2025Article
- Diversity and Evolution of Frog Visual Opsins: Spectral Tuning and Adaptation to Distinct Light Environments.Molecular biology and evolution · 2024Article
- Transcriptomic evidence for visual adaptation during the aquatic to terrestrial metamorphosis in leopard frogs.BMC biology · 2022Article
- Evolutionary analyses of visual opsin genes in frogs and toads: Diversity, duplication, and positive selection.Ecology and evolution · 2022Article
- Eye-Transcriptome and Genome-Wide Sequencing for Scolecophidia: Implications for Inferring the Visual System of the Ancestral Snake.Genome biology and evolution · 2021Article
- Article
- What the salamander eye has been telling the vision scientist's brain.Seminars in cell & developmental biology · 2020Review
- The visual pigment xenopsin is widespread in protostome eyes and impacts the view on eye evolution.eLife · 2020Article
- Visual pigment evolution in Characiformes: The dynamic interplay of teleost whole-genome duplication, surviving opsins and spectral tuning.Molecular ecology · 2020Article
- Salamanders and other amphibians are aglow with biofluorescence.Scientific reports · 2020Article
- Exposure to Artificial Light at Night and the Consequences for Flora, Fauna, and Ecosystems.Frontiers in neuroscience · 2020Review
- Co-expression of xenopsin and rhabdomeric opsin in photoreceptors bearing microvilli and cilia.eLife · 2017Article
- Evolutionary transformation of rod photoreceptors in the all-cone retina of a diurnal garter snake.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Spectral tuning by opsin coexpression in retinal regions that view different parts of the visual field.Proceedings. Biological sciences · 2014Article
- Membrane guanylyl cyclase complexes shape the photoresponses of retinal rods and cones.Frontiers in molecular neuroscience · 2014Review
- Article
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
Although more than one type of visual opsin is present in the retina of most vertebrates, it was thought that each type of photoreceptor expresses only one opsin. However, evidence has accumulated that some photoreceptors contain more than one opsin, in many cases as a result of a developmental transition from the expression of one opsin to another. The salamander UV-sensitive (UV) cone is particularly notable because it contains three opsins (Makino and Dodd [1996] J Gen Physiol 108:27-34). Two opsin types are expressed at levels more than 100 times lower than the level of the primary opsin. Here, immunohistochemical experiments identified the primary component as a UV cone opsin and the two minor components as the short wavelength-sensitive (S) and long wavelength-sensitive (L) cone opsins. Based on single-cell recordings of 156 photoreceptors, the presence of three components in UV cones of hatchlings and terrestrial adults ruled out a developmental transition. There was no evidence for multiple opsin types within rods or S cones, but immunohistochemistry and partial bleaching in conjunction with single-cell recording revealed that both single and double L cones contained low levels of short wavelength-sensitive pigments in addition to the main L visual pigment. These results raise the possibility that coexpression of multiple opsins in other vertebrates was overlooked because a minor component absorbing at short wavelengths was masked by the main visual pigment or because the expression level of a component absorbing at long wavelengths was exceedingly low.
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