ArticleMaternal and child health journal2014
Patterns of prescription of antidepressants and antipsychotics across and within pregnancies in a population-based UK cohort.
Article in Maternal and child health journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Antidepressant Use During Pregnancy and Birth Outcomes: Analysis From the UK, Norway, and Sweden.Pharmacoepidemiology and drug safety · 2026Article
- Antipsychotic Discontinuation and Re-initiation in Pregnant Women With Schizophrenia: A Retrospective Cohort Study From South Korea.Schizophrenia bulletin · 2026Article
- Patterns of antidepressant prescribing around pregnancy: a descriptive analysis using Clinical Practice Research Datalink GOLD.The British journal of general practice : the journal of the Royal College of General Practitioners · 2026Article
- Medication use from conception to the first antenatal appointment: agreement between maternal self-report to midwife and prescribing records in Northern Ireland in 2011-2016.International journal of population data science · 2025Article
- Stakeholder views on the design of National Health Service perinatal mental health services: 360-degree survey.BJPsych bulletin · 2024Article
- Sertraline, citalopram and paroxetine in lactation: passage into breastmilk and infant exposure.Frontiers in pharmacology · 2024Article
- Prenatal antidepressant exposure and emotional disorders until age 22: a danish register study.Child and adolescent psychiatry and mental health · 2023Article
- Antipsychotic utilization patterns in pregnant women with psychotic disorders: a 16-year population-based cohort study.European archives of psychiatry and clinical neuroscience · 2023Article
- Allopregnanolone Concentrations in Breast Milk and Plasma from Healthy Volunteers Receiving Brexanolone Injection, With Population Pharmacokinetic Modeling of Potential Relative Infant Dose.Clinical pharmacokinetics · 2022Article
- Treatment of Peripartum Depression with Antidepressants and Other Psychotropic Medications: A Synthesis of Clinical Practice Guidelines in Europe.International journal of environmental research and public health · 2022Review
- In utero exposure to antipsychotic medication and psychiatric outcomes in the offspring.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Treating Anxiety During Pregnancy: Patient Concerns About Pharmaceutical Treatment.Maternal and child health journal · 2020Article
- The Association Between Prenatal Exposure to Antidepressants and Autism: Some Research and Public Health Aspects.Frontiers in psychiatry · 2020Review
- Second-generation antipsychotics and pregnancy complications.European journal of clinical pharmacology · 2020Article
- Association of Autism Spectrum Disorder With Prenatal Exposure to Medication Affecting Neurotransmitter Systems.JAMA psychiatry · 2018Article
- Antipsychotic Medication Use Among Publicly Insured Pregnant Women in the United States.Psychiatric services (Washington, D.C.) · 2017Article
- Psychotropic Drug Use before, during, and after Pregnancy: A Population-Based Study in a Canadian Cohort (2001-2013).Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2017Article
- The Perinatal Treatment Conundrum.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2017Article
- Article
- [Affective disorders during pregnancy : Therapy with antidepressants and mood stabilizers].Der Nervenarzt · 2016Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although antidepressant and antipsychotic utilization by gestational trimester has been described, longitudinal prescription patterns within pregnancies have received less attention. All mothers in the Clinical Practice Research Datalink's Mother Baby Link enrolled from 6 months before pregnancy to 3 months after delivery, with delivery date between 01/1989 and 12/2010 were included (n = 421,645). Drug use prevalence was calculated as the number of women with prescriptions for antidepressants or antipsychotics in capsules/tablets in the 3 months before pregnancy (T0), the first (T1), second (T2), or third (T3) pregnancy trimesters, or the 3 months after delivery (T4). In each pregnancy, prescriptions in T0 and T3 were compared to identify treatment discontinuation, simplification (some drugs discontinued or dose lowered), no treatment change, intensification (drugs added to prior treatment or dose increased), and start. Antidepressant use in T0 through T4 was 4.69, 2.81, 1.31, 1.34, and 5.46 %, respectively. Of 19,774 T0 antidepressant users, 79.57 % discontinued, 5.13 % simplified, 9.06 % did not change, and 2.19 % intensified treatment. 0.40 % of non-users in T0 started antidepressants by T3. Antipsychotic use in T0 through T4 was 0.57, 1.34, 0.54, 0.28 and 0.38 %. Excluding prochlorperazine, it was 0.15, 0.13, 0.08, 0.07 and 0.15 %, respectively; of 639 T0 users, 72.30 % discontinued, 7.51 % simplified, 11.11 % did not change, and 4.07 % intensified treatment. 0.03 % of non-users in T0 started antipsychotics by T3. Cross-sectional and longitudinal analyses identified a post-conception decrease in antidepressant and antipsychotic prescribing. Longitudinal treatment assessment additionally captured several treatment patterns among those who do not discontinue treatment that usually stay unrecognized.
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