ArticleDigestive diseases and sciences2014
Characteristics of patients who avoid wheat and/or gluten in the absence of Celiac disease.
Article in Digestive diseases and sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 57 citations in OpenAlex.
- The Effect of Gluten Free Diet on Components of Metabolic Syndrome: A Randomized Clinical TrialAsian Pacific journal of cancer prevention : APJCP · 2018Trial
- Non-celiac Gluten Intolerance: A Call to Clarify.Digestive diseases and sciences · 2023Article
- Investigation of the Factors Affecting Bone Mineral Density in Children with Celiac Disease.Pediatric gastroenterology, hepatology & nutrition · 2022Article
- "The Gluten-Free Diet and Its Relationship with Metabolic Syndrome: Dietary Friend or Foe?"Current nutrition reports · 2021Review
- Non-Celiac Gluten Sensitivity in the Context of Functional Gastrointestinal Disorders.Nutrients · 2020Review
- Characteristics and Maternal-Fetal Outcomes of Pregnant Women Without Celiac Disease Who Avoid Gluten.Digestive diseases and sciences · 2020Observational
- Going Against the Grains: Gluten-Free Diets in Patients Without Celiac Disease-Worthwhile or Not?Digestive diseases and sciences · 2019Review
- Concise Commentary: Gluten-Free Diets-You've Gotta Believe in Something.Digestive diseases and sciences · 2018Article
- Skepticism Regarding Vaccine and Gluten-Free Food Safety Among Patients with Celiac Disease and Non-celiac Gluten Sensitivity.Digestive diseases and sciences · 2018Article
- Non-celiac gluten sensitivity: people without celiac disease avoiding gluten-is it due to histamine intolerance?Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2018Review
- Non-evidence-Based Medicine: The Gastroenterologist's Role and Responsibility.Digestive diseases and sciences · 2018Article
- Depression and insomnia among individuals with celiac disease or on a gluten-free diet in the USA: results from a national survey.European journal of gastroenterology & hepatology · 2017Article
- Less Hidden Celiac Disease But Increased Gluten Avoidance Without a Diagnosis in the United States: Findings From the National Health and Nutrition Examination Surveys From 2009 to 2014.Mayo Clinic proceedings · 2016Article
- Nonceliac Gluten Sensitivity.Advances in nutrition (Bethesda, Md.) · 2016Review
- Self-Reported Food Hypersensitivity: Prevalence, Characteristics, and Comorbidities in the Norwegian Women and Cancer Study.PloS one · 2016Article
- Celiac disease and non-celiac gluten sensitivity.BMJ (Clinical research ed.) · 2015Review
- Practical insights into gluten-free diets.Nature reviews. Gastroenterology & hepatology · 2015Review
- The spectrum of noncoeliac gluten sensitivity.Nature reviews. Gastroenterology & hepatology · 2015Review
- Exploring the Strange New World of Non-Celiac Gluten Sensitivity.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2015Article
- Cost Effectiveness of Routine Duodenal Biopsy Analysis for Celiac Disease During Endoscopy for Gastroesophageal Reflux.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2015Article
Corrections and comments
- Commented on by
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGastrointestinal symptoms that respond to the removal of wheat and/or gluten are becoming more common. Patients who avoid wheat and/or gluten (PWAWG) are a heterogeneous group and predominantly self-diagnosed prior to presenting for clinical evaluation. SPECIFIC
aimWe characterized PWAWGs seen at a tertiary care referral center and compared them to patients with celiac disease (CD) and subjects in the National Health and Nutrition examination survey (NHANES).
methodsThis was a cross-sectional study evaluating patients seen by four gastroenterologists at a CD referral center. Baseline characteristics, laboratory values, and medical comorbidities were compared to CD patients who presented at the same center and subjects enrolled in NHANES.
resultsEighty-four PWAWGs were identified and compared to 585 CD patients and 2,686 NHANES patients. Thirty-two alternative diagnoses were made in 25 (30%) PWAWGs, including small intestinal bacterial overgrowth and fructose/lactose intolerance. When compared to patients with CD, PWAWGs had similar body mass index (BMI, 23.1 vs. 23.5, p = 0.54) and mean hemoglobin value (13.4 vs. 13.3, p = 0.6). When compared to male and female patients in NHANES, BMI, folate, and mean hemoglobin values were lower in PWAWGs. Both male and female PWAWGs had a lower prevalence of hypertension.
conclusionWhile there are similarities between CD and PWAWGs that could possibly be due to shared HLA haplotypes or an effect of the gluten-free diet, alternative diagnoses are common in these patients. PWAWGs have a similar cardiovascular profile as CD patients in terms of lower BMI and lower prevalence of hypertension.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.