Evidence map›Paper›PMID 24374554›Full record

ReviewMammalian genome : official journal of the International Mammalian Genome Society2014

The genetics of gene expression in complex mouse crosses as a tool to study the molecular underpinnings of behavior traits.

Robert Hitzemann, Daniel Bottomly, Ovidiu Iancu, Kari Buck, Beth Wilmot, Michael Mooney, Robert Searles, Christina Zheng, John Belknap, John Crabbe and 1 more

Abstract readReview
In one paragraph

Review in Mammalian genome : official journal of the International Mammalian Genome Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Genetics of gene expression in CNS.International review of neurobiology · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Robert HitzemannPortland Alcohol Research Center, Veterans Affairs Medical Center, Portland, 97239, OR, USA.
Daniel Bottomly
Ovidiu Iancu
Kari Buck
Beth Wilmot
Michael Mooney
Robert Searles
Christina Zheng
John Belknap
John Crabbe
Shannon McWeeney

Funding

OREGON CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024140 · NCRR · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2006 to 2011
$61.1M
Understanding the origins of rapid recurrence of pancreatic cancer after resectionP30CA069533 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Grace B Gill · 1997 to 2026
$60.5M
Translational measures of risk for excessive alcohol consumptionP60AA010760 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI TAMARA J. PHILLIPS · 2006 to 2026
$34.5M
Selective Breeding for Drinking in the Circadian DarkU01AA013519 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Angela Renee Ozburn · 2001 to 2026
$10.9M
THERMAL AND METABOLIC DYSFUNCTION DURING WITHDRAWALP50AA010760 · NIAAA · OREGON HEALTH AND SCIENCE UNIVERSITY · PI CRABBE, JOHN C. · 1996 to 2005
$10.7M
Neurocircuitry Mapping and Genotyping CoreU01AA013484 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI HITZEMANN, ROBERT J. · 2001 to 2021
$6.2M
Mapping the Genes for Ethanol-Related PhenotypesR01AA011034 · NIAAA · STATE UNIVERSITY NEW YORK STONY BROOK · PI HITZEMANN, ROBERT J. · 1996 to 2014
$5.1M
GENETIC VULNERABILITY TO DRUGS OF ABUSER01DA005228 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI BUCK, KARI J · 1989 to 2015
$4.6M
MAPPING THE GENES FOR NEUROLEPTIC RESPONSER01MH051372 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI HITZEMANN, ROBERT J. · 1995 to 2014
$4.0M
Mouse Genetic Models for Alcohol ResearchR24AA020245 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI PHILLIPS, TAMARA J. · 2011 to 2020
$2.3M
Genetic Models of AlcoholismI01BX000313 · VA · PORTLAND VA MEDICAL CENTER · PI CRABBE, JOHN C. · 2009 to 2019
–
BLRD VA I01 BX000313NCI NIH HHS 5P30 CA069533NCI NIH HHS P30 CA069533NCRR NIH HHS 5UL1 RR024140NCRR NIH HHS UL1 RR024140NIAAA NIH HHS AA10760NIAAA NIH HHS AA11034NIAAA NIH HHS AA13484NIAAA NIH HHS AA13519NIAAA NIH HHS AA20245NIAAA NIH HHS P50 AA010760NIAAA NIH HHS P60 AA010760NIAAA NIH HHS R01 AA011034NIAAA NIH HHS R24 AA020245NIAAA NIH HHS U01 AA013484NIAAA NIH HHS U01 AA013519NIDA NIH HHS DA005228NIDA NIH HHS R01 DA005228NIMH NIH HHS MH51372NIMH NIH HHS R01 MH051372
6 · The paper itself

Abstract

Complex Mus musculus crosses provide increased resolution to examine the relationships between gene expression and behavior. While the advantages are clear, there are numerous analytical and technological concerns that arise from the increased genetic complexity that must be considered. Each of these issues is discussed, providing an initial framework for complex cross study design and planning.

Indexed as

Crosses, GeneticGene ExpressionGenetics, BehavioralQuantitative Trait, HeritableAnimalsGenetics, PopulationGenomicsMicePhenotypeQuantitative Trait Loci

Identifiers

PMID24374554
PMCPMC3916704

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.