ArticleThe protein journal2014
Purification and characterization of antioxidant peptides from leukocyte extract of Crocodylus siamensis.
Article in The protein journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Identification and Functional Characterization of Cytoprotective Crocodile-Derived Peptides against Oxidatively Stressed Human Keratinocytes.ACS omega · 2026Article
- Antioxidant Synergy ofACS omega · 2026Article
- Bioactive Peptides from Fermented Foods: Production Approaches, Sources, and Potential Health Benefits.Foods (Basel, Switzerland) · 2024Review
- Inhibitory Effects ofPreventive nutrition and food science · 2023Article
- Separation and Purification of Antioxidant Peptide from Fermented Whey Protein byFood science of animal resources · 2023Article
- Crocodile blood supplementation protects vascular function in diabetic mice.Food production, processing and nutrition · 2021Article
- Histopathology of murine toxoplasmosis under treatment with dialyzable leukocyte extract.Memorias do Instituto Oswaldo Cruz · 2017Article
- Protective Effect of Crocodile Hemoglobin and Whole Blood Against Hydrogen Peroxide-Induced Oxidative Damage in Human Lung Fibroblasts (MRC-5) and Inflammation in Mice.Inflammation · 2017Article
- Cationic Antimicrobial Peptides Derived from Crocodylus siamensis Leukocyte Extract, Revealing Anticancer Activity and Apoptotic Induction on Human Cervical Cancer Cells.The protein journal · 2016Article
- An investigation of antioxidant and anti-inflammatory activities from blood components of Crocodile (Crocodylus siamensis).The protein journal · 2014Article
- Antimicrobial peptides in reptiles.Pharmaceuticals (Basel, Switzerland) · 2014Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antioxidant peptides were isolated from the leukocyte extract of the Siamese crocodile, Crocodylus siamensis. Crocodile leukocyte was extracted by a combination of methods including freeze-thawing, acetic acid extraction and homogenization. The peptides in the leukocyte extract were purified by anion exchange chromatography and reversed phase-high performance liquid chromatography. The 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay was used to evaluate the antioxidant activity of the elution peaks at each purification step. As a result, there were two purified peptides exhibiting strong antioxidant activity in reducing free radicals on DPPH molecules. The amino acid sequences of these peptides were determined by LC-MS/MS as TDVLGLPAK (912.5 Da) and DPNAALPAGPR (1,148.6 Da), and their IC₅₀ values were 153.4 and 95.7 μM, respectively. The results of this study therefore indicate that leukocyte extract of C. siamensis contains peptides with antioxidant activity which could be used as a novel antioxidant.
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