Evidence map›Paper›PMID 24374271›Full record

ArticleBioorganic & medicinal chemistry letters2014

Bifunctional thiosialosides inhibit influenza virus.

Yang Yang, Yun He, Xingzhe Li, Hieu Dinh, Suri S Iyer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Electrochemical assay to detect influenza viruses and measure drug susceptibility.Angewandte Chemie (International ed. in English) · 2015
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yang Yang788 Petit Science Center, Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30302, United States.
Yun He788 Petit Science Center, Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30302, United States.
Xingzhe Li788 Petit Science Center, Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30302, United States.
Hieu Dinh788 Petit Science Center, Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30302, United States.
Suri S Iyer788 Petit Science Center, Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30302, United States. Electronic address: siyer@gsu.edu.

Funding

Receptor Mimics for Rapid Detection, Typing, and Susceptibility Testing of InflueR01AI089450 · NIAID · UNIVERSITY OF CINCINNATI · PI IYER, SURI SARANATHAN, WEISS, ALISON A. · 2010 to 2014
$2.2M
NIAID NIH HHS R01 AI089450NIAID NIH HHS R01-AI089450
6 · The paper itself

Abstract

We have synthesized a panel of bivalent S-sialoside analogues, with modifications at the 4 position, as inhibitors of influenza virus. These first generation compounds show IC50 values ranging from low micromolar to high nanomolar in enzyme inhibition and plaque reduction assays with two intact viruses, Influenza H1N1 (A/California/07/2009) and H3N2 (A/Hongkong/8/68).

Indexed as

Antiviral AgentsHumansInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeN-Acetylneuraminic AcidAntiviral AgentsN-Acetylneuraminic AcidBifunctionalGlycoconjugatesInfluenza virusInhibitorsSialic acid

Identifiers

PMID24374271
PMCPMC4397911

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.