ArticleJournal of insect physiology2014
The role of serotonin in feeding and gut contractions in the honeybee.
Article in Journal of insect physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 96 citations in OpenAlex.
- Establishment and Validation of a CUMS Model for Depression-like Behavior in Honeybees: A Tool for Pollinator Stress Research.Insects · 2026Article
- Comprehension of the age-dependent gut and brain interaction of honey bee workers by integration of multi omics approaches.Journal of advanced research · 2026Article
- What goes down may come up: regurgitative behaviors and their underlying gut-brain axes-insights from genetic models and related pathologies.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Review
- The serotonin receptor AmFrontiers in physiology · 2026Article
- Oxygen-dependent regulation of serotonin receptoriScience · 2025Article
- Convergent Molecular Evolution Associated With Repeated Transitions to Gregarious Larval Behavior in Heliconiini.Molecular biology and evolution · 2025Article
- Serotonin signaling to regulate energy metabolism: a gut microbiota perspective.Life metabolism · 2025Review
- Sequence-Based Multi Ancestry Association Study Reveals the Polygenic Architecture of Varroa destructor Resistance in the Honeybee Apis mellifera.Molecular ecology · 2025Article
- Phylogenomics of the psychoactive mushroom genusProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Regulation of forager honey bee appetite independent of the glucose-insulin signaling pathway.Frontiers in insect science · 2024Article
- Task-specific odorant receptor expression in worker antennae indicates that sensory filters regulate division of labor in ants.Communications biology · 2023Article
- Article
- Ingested histamine and serotonin interact to alterFrontiers in physiology · 2023Article
- Supplementation in vitamin B3 counteracts the negative effects of tryptophan deficiencies in bumble bees.Conservation physiology · 2023Article
- Identification and Pharmacological Characterization of Two Serotonin Type 7 Receptor Isoforms fromInternational journal of molecular sciences · 2022Article
- Conceptual framework for the insect metamorphosis from larvae to pupae by transcriptomic profiling, a case study of Helicoverpa armigera (Lepidoptera: Noctuidae).BMC genomics · 2022Article
- Deletion of the Serotonin Receptor 7 Gene Changed the Development and Behavior of the Mosquito,Insects · 2022Article
- Characterizing serotonin biosynthesis in Setaria viridis leaves and its effect on aphids.Plant molecular biology · 2022Article
- Conditioned taste aversion in the cricket Gryllus bimaculatus.Scientific reports · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serotonin (5-hydroxytryptamine, 5-HT) is involved in the regulation of feeding and digestion in many animals from worms to mammals. In insects, 5-HT functions both as a neurotransmitter and as a systemic hormone. Here we tested its role as a neurotransmitter in feeding and crop contractions and its role as a systemic hormone that affected feeding in adult foraging honeybees. We found 5-HT immunoreactive processes throughout the gut, including on the surface of the oesophagus, crop, proventriculus, and the midgut, as well as in the ventral nerve cord. mRNA transcripts for all four of the known bee 5-HT receptors (Am5-ht1A,2α,2β,7) were expressed in the crop and the midgut suggesting a functional role for 5-HT in these locations. Application of a cocktail of antagonists with activity against these known receptors to the entire gut in vivo reduced the rate of spontaneous contraction in the crop and proventriculus. Although feeding with sucrose caused a small elevation of endogenous 5-HT levels in the haemolymph, injection of exogenous 5-HT directly into the abdomen of the bee to elevate 5-HT in the haemolymph did not alter food intake. However, when 5-HT was injected into directly into the brain there was a reduction in intake of carbohydrate, amino acid, or toxin-laced food solutions. Our data demonstrate that 5-HT inhibits feeding in the brain and excites muscle contractions in the gut, but general elevation of 5-HT in the bee's haemolymph does not affect food intake.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.