Evidence map›Paper›PMID 24374086›Full record

ArticlePsychosomatics

Do platelet-derived microparticles play a role in depression, inflammation, and acute coronary syndrome?

Marlene S Williams, Heather L Rogers, Nae-Yuh Wang, Roy C Ziegelstein

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychosomatics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
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  4. Depression Following Acute Coronary Syndrome: A Review.Reviews in cardiovascular medicine · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Marlene S WilliamsDepartment of Medicine, Johns Hopkins University, Baltimore, MD. Electronic address: mwillia1@jhmi.edu.
Heather L RogersDepartment of Methodology and Experimental Psychology, University of Deusto, Biscay, Spain.
Nae-Yuh WangDepartment of Medicine, Johns Hopkins University, Baltimore, MD.
Roy C ZiegelsteinDepartment of Medicine, Johns Hopkins University, Baltimore, MD.
Johns Hopkins University · USUniversidad de Deusto · ES

Funding

Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Center for Mind-Body ResearchR24AT004641 · NCCIH · JOHNS HOPKINS UNIVERSITY · PI HAYTHORNTHWAITE, JENNIFER A · 2007 to 2009
$2.9M
Mechanisms of Platelet Activation in Depression and Acute Coronary SyndromesR01HL096694 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI WILLIAMS, MARLENE S · 2010 to 2014
$2.0M
NCATS NIH HHS UL1 TR001079NCCIH NIH HHS R24 AT004641NCCIH NIH HHS R24AT004641NCRR NIH HHS UL1 RR025005NCRR NIH HHS UL1RR025005NHLBI NIH HHS R01 HL096694NHLBI NIH HHS R01HL096694
6 · The paper itself

Abstract

backgroundMajor depression is an independent predictor of increased mortality in patients presenting with acute coronary syndromes (ACS). There have been several mechanisms proposed to explain the link between depression and ischemic heart disease. Both abnormal platelet physiology and inflammation have been suggested as potential confounding variables.

objectiveWe set out to examine platelet activation, inflammation, and levels of depression in hospitalized patients presenting with ACS.

methodsWe enrolled 28 patients with ACS and assessed levels of depression by PHQ-9. Platelet activation was assessed by the measurement of platelet microparticle levels and platelet aggregation to adenosine diphosphate and serotonin. Inflammatory markers were assessed by the measurement of TNF alpha, IL-6, and CRP.

resultsWe found that ACS patients with moderate depressive symptoms who had higher TNF alpha, IL-6, and CRP levels had higher levels of platelet microparticles. We also found that ACS patients with PHQ-9 ≥ 10 had higher platelet aggregation to ADP.

conclusionOur results suggest that patients hospitalized for the treatment of an ACS who have moderate depression have increased platelet aggregation. These patients also have a positive association between elevated inflammatory markers and platelet activation, thus suggesting a pro-inflammatory component in ACS patients with depressive symptoms that may alter platelet function. These results are intriguing in that a potential pathway to explain the connection between depression, inflammation, and increased cardiovascular thrombosis might be found when both platelet activation and inflammation are measured.

Indexed as

Cell-Derived MicroparticlesAcute Coronary SyndromeAgedAged, 80 and overBiomarkersBlood PlateletsC-Reactive ProteinDepressionFemaleHumansInflammationInterleukin-6MaleMiddle AgedPlatelet ActivationTumor Necrosis Factor-alphaBiomarkersC-Reactive ProteinIL6 protein, humanInterleukin-6Tumor Necrosis Factor-alpha

Identifiers

PMID24374086
PMCPMC4004656
OpenAlexW2081264740

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.