Evidence map›Paper›PMID 24373842›Full record

ArticleBioorganic & medicinal chemistry2014

Structurally diverse low molecular weight activators of the mammalian pre-mRNA 3' cleavage reaction.

Min Ting Liu, Nagaraja N Nagre, Kevin Ryan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Min Ting LiuDepartment of Chemistry, The City College of New York, The City University of New York, New York, NY 10031, USA.
Nagaraja N NagreDepartment of Chemistry, The City College of New York, The City University of New York, New York, NY 10031, USA.
Kevin RyanDepartment of Chemistry, The City College of New York, The City University of New York, New York, NY 10031, USA. Electronic address: kr107@sci.ccny.cuny.edu.
City College of New York · US

Funding

TNC FUNCTION IN APOPTOTIC ANTIGEN DRIVEN AUTOIMMUNITYG12RR003060 · NCRR · CITY COLLEGE OF NEW YORK · PI WALLMAN, JOSHUA · 1985 to 2011
$26.1M
Cellular/Molecular Basis of Development: Research CenterG12MD007603 · NIMHD · CITY COLLEGE OF NEW YORK · PI PEZZANO, MARK · 2012 to 2017
$11.5M
Protein phosphorylation in pre-mRNA 3' cleavageSC1GM083754 · NIGMS · CITY COLLEGE OF NEW YORK · PI RYAN, KEVIN · 2009 to 2012
$1.0M
NCRR NIH HHS 2G12RR03060-26A1NCRR NIH HHS G12 RR003060NIGMS NIH HHS 5SC1GM083754NIGMS NIH HHS SC1 GM083754NIMHD NIH HHS 8G12MD007603-27NIMHD NIH HHS G12 MD007603
6 · The paper itself

Abstract

The 3' end formation of mammalian pre-mRNA contributes to gene expression regulation by setting the downstream boundary of the 3' untranslated region, which in many genes carries regulatory sequences. A large number of protein cleavage factors participate in this pre-mRNA processing step, but chemical tools to manipulate this process are lacking. Guided by a hypothesis that a PPM1 family phosphatase negatively regulates the 3' cleavage reaction, we have found a variety of new small molecule activators of the in vitro reconstituted pre-mRNA 3' cleavage reaction. New activators include a cyclic peptide PPM1D inhibitor, a dipeptide with modifications common to histone tails, abscisic acid and an improved l-arginine β-naphthylamide analog. The minimal concentration required for in vitro cleavage has been improved from 200μM to the 200nM-100μM range. These compounds provide unexpected leads in the search for small molecule tools able to affect pre-mRNA 3' end formation.

Indexed as

Dose-Response Relationship, DrugHeLa CellsHumansMolecular StructureMolecular WeightPeptides, CyclicRNA 3' End ProcessingStructure-Activity RelationshipPeptides, Cyclic3′ end formationHistone codeNaphthalene ringPolyadenylationRNARNA processingSmall molecule activators

Identifiers

PMID24373842
PMCPMC4018835
OpenAlexW2058407439

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.