ArticleCancer epidemiology2014
Breast cancer susceptibility loci in association with age at menarche, age at natural menopause and the reproductive lifespan.
Article in Cancer epidemiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genetic Variation and Hot Flashes: A Systematic Review.The Journal of clinical endocrinology and metabolism · 2020Pooled it
- Association between age at menarche and the risk of myopia at the age of 15 in Chongqing, China: a cross-sectional study.Frontiers in medicine · 2025Article
- Associations between single-nucleotide polymorphisms of the interleukin-18 gene and breast cancer in Iraqi women.Genomics & informatics · 2022Article
- Effect of Interaction between Early Menarche and Genetic Polymorphisms on Triglyceride.Oxidative medicine and cellular longevity · 2019Article
- Genetics of pubertal timing.Current opinion in pediatrics · 2018Review
- Genetic variants associated with earlier age at menopause increase the risk of cardiovascular events in women.Menopause (New York, N.Y.) · 2018Article
- Semiparametric analysis of complex polygenic gene-environment interactions in case-control studies.Biometrika · 2017Article
- Interaction between common breast cancer susceptibility variants, genetic ancestry, and nongenetic risk factors in Hispanic women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2015Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundGenome-wide association studies have identified single nucleotide polymorphisms (SNPs) associated with breast cancer risk. Some of these loci have unknown functional significance and may mediate the effects of hormonal exposures on breast cancer risk. We examined relationships between breast cancer susceptibility variants and menstrual/reproductive factors using data from two population-based studies.
methodsThe first analysis was based on a sample of 1328 women age 20-74 who participated as controls in a case-control study of breast cancer conducted in three U.S. states. We evaluated the associations between age at menarche, age at natural menopause and the reproductive lifespan with 13 previously identified breast cancer variants. Associations were also examined with a genetic score created as the sum of at-risk alleles across the 13 variants. For validation, significant results were evaluated in a second dataset comprised 1353 women age 43-86 recruited as part of a cohort study in Wisconsin.
resultsNeither the genetic score nor any of the 13 variants considered individually were associated with age at menarche or reproductive lifespan. Two SNPs were associated with age at natural menopause; every increase in the minor allele (A) of rs17468277 (CASP8) was associated with a 1.12 year decrease in menopause age (p=0.02). The minor allele (G) of rs10941679 (5p12) was associated with a 1.01 year increase in age at natural menopause (p=0.01). The results were not replicated in the validation cohort (B=-0.61, p=0.14 and B=-0.01, p=.0.98, respectively).
conclusionsThe evaluated variants and reproductive experiences may work through separate pathways to influence breast cancer risk.
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