ArticleBMC urology2013
Addressing the contribution of previously described genetic and epidemiological risk factors associated with increased prostate cancer risk and aggressive disease within men from South Africa.
Article in BMC urology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prostate adenocarcinoma associated with prostatic infection due to Schistosoma haematobium. Case report and systematic review.Parasitology research · 2015Pooled it
- Men's Knowledge, Attitudes, Practices, Cultural Beliefs, and Perceived Risk and Susceptibility Regarding Prostate Cancer in the Vhembe District, Limpopo Province, South Africa.Journal of racial and ethnic health disparities · 2026Article
- Biochemical progression free and overall survival among Black men with stage IV prostate cancer in South Africa: Results from a prospective cohort study.Cancer medicine · 2024Article
- Prostate cancer genetic risk and associated aggressive disease in men of African ancestry.Nature communications · 2023Article
- Linking African ancestral substructure to prostate cancer health disparities.Scientific reports · 2023Article
- Metagenomic analysis reveals a rich bacterial content in high-risk prostate tumors from African men.The Prostate · 2019Article
- African KhoeSan ancestry linked to high-risk prostate cancer.BMC medical genomics · 2019Article
- Prostate cancer genomics and racial health disparity.Oncotarget · 2018Article
- Prostate Cancer in Southern Africa: Does Africa Hold Untapped Potential to Add Value to the Current Understanding of a Common Disease?Journal of global oncology · 2018Article
- Prostate Cancer Burden at the Uganda Cancer Institute.Journal of global oncology · 2016Article
- Spectrum of mitochondrial genomic variation and associated clinical presentation of prostate cancer in South African men.The Prostate · 2016Article
- Analysis of Prostate Cancer Susceptibility Variants in South African Men: Replicating Associations on Chromosomes 8q24 and 10q11.Prostate cancer · 2015Article
- Clinical presentation of prostate cancer in black South Africans.The Prostate · 2014Article
- Prostate Cancer Genomics Research Disparities in Africa: Advancing Knowledge in Resource Constrained Settings.Cancer control : journal of the Moffitt Cancer CenterArticle
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Authors and funding
7 authors.
Funding
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Abstract
backgroundAlthough African ancestry represents a significant risk factor for prostate cancer, few studies have investigated the significance of prostate cancer and relevance of previously defined genetic and epidemiological prostate cancer risk factors within Africa. We recently established the Southern African Prostate Cancer Study (SAPCS), a resource for epidemiological and genetic analysis of prostate cancer risk and outcomes in Black men from South Africa. Biased towards highly aggressive prostate cancer disease, this is the first reported data analysis.
methodsThe SAPCS is an ongoing population-based study of Black men with or without prostate cancer. Pilot analysis was performed for the first 837 participants, 522 cases and 315 controls. We investigate 46 pre-defined prostate cancer risk alleles and up to 24 epidemiological measures including demographic, lifestyle and environmental factors, for power to predict disease status and to drive on-going SAPCS recruitment, sampling procedures and research direction.
resultsPreliminary results suggest that no previously defined risk alleles significantly predict prostate cancer occurrence within the SAPCS. Furthermore, genetic risk profiles did not enhance the predictive power of prostate specific antigen (PSA) testing. Our study supports several lifestyle/environmental factors contributing to prostate cancer risk including a family history of cancer, diabetes, current sexual activity and erectile dysfunction, balding pattern, frequent aspirin usage and high PSA levels.
conclusionsDespite a clear increased prostate cancer risk associated with an African ancestry, experimental data is lacking within Africa. This pilot study is therefore a significant contribution to the field. While genetic risk factors (largely European-defined) show no evidence for disease prediction in the SAPCS, several epidemiological factors were associated with prostate cancer status. We call for improved study power by building on the SAPCS resource, further validation of associated factors in independent African-based resources, and genome-wide approaches to define African-specific risk alleles.
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