Evidence map›Paper›PMID 24373617›Full record

ArticleBMC musculoskeletal disorders2013

Relevant baseline characteristics for describing patients with knee osteoarthritis: results from a Delphi survey.

Lukas M Wildi, Anita Hensel, Maria Wertli, Beat A Michel, Johann Steurer

Abstract read
In one paragraph

Article in BMC musculoskeletal disorders, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Lukas M WildiDepartment of Rheumatology, University Hospital of Zurich, Gloriastrasse 25, 8091 Zurich, Switzerland. lukas.wildi@usz.ch.
Anita Hensel
Maria Wertli
Beat A Michel
Johann Steurer

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInclusion/exclusion criteria and baseline characteristics are essential for assessing the applicability of trial results to a given patient and the comparability of study populations for meta-analyses. This Delphi survey aimed to generate a set of baseline characteristics for describing patients with knee osteoarthritis enrolled in clinical studies.

methodsSurvey participants comprised clinical experts (n = 23; mean age 54 y; from 4 continents) that had authored at least two randomized trials on knee osteoarthritis. First, given a prepared list of baseline patient characteristics, the experts were asked to add characteristics they considered important for assessing comparability of patient populations in different trials that evaluated the efficacy of non-surgical interventions for treating knee osteoarthritis. Next, they were asked to rate the importance of each characteristic, on a scale of 0 (not important) to 10 (highly important), according to three outcome categories: pain, function, and structure.

resultsParticipants identified 121 baseline characteristics. A rating ≥7 points was assigned to 39 characteristics (e.g., age, depression, global knee pain, daily dose of pain killers, Kellgren-Lawrence grading); of these, 20 were related to pain, 15 to function, and 23 to structural outcomes. Global knee pain was the only baseline characteristic that fulfilled among experts the predefined consensus criteria.

conclusionsExperts identified a large number of characteristics for describing patients with knee osteoarthritis. Disagreement and uncertainty prevailed over the relevance of these characteristics. Our findings justified further efforts to define appropriate, broadly acceptable sets of baseline characteristics for describing patients with knee osteoarthritis.

Indexed as

Osteoarthritis, KneeAdultAgedDelphi TechniqueFemaleHumansMaleMiddle AgedRheumatology

Identifiers

PMID24373617
PMCPMC3882493

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