Trial reportEnvironmental health : a global access science source2013
An indoor air filtration study in homes of elderly: cardiovascular and respiratory effects of exposure to particulate matter.
Trial report in Environmental health : a global access science source, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03104387 (Effects of Diesel Combustion Generated Air Pollution on Cardiovascular Function and Oxidatively Damaged DNA in Healthy Volunteers), which is not on this map. Cited by 46 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Diesel Combustion Generated Air Pollution on Cardiovascular Function and Oxidatively Damaged DNA in Healthy Volunteers
Who cites it
46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 121 citations in OpenAlex.
- Effectiveness of particulate matter filtration: systematic review and meta-analysis.Revista brasileira de enfermagem · 2026Pooled it
- Effectiveness of indoor air purification intervention in improving cardiovascular health: A systematic review and meta-analysis of randomized controlled trials.The Science of the total environment · 2021Pooled it
- Effects of Home Particulate Air Filtration on Blood Pressure: A Systematic Review.Hypertension (Dallas, Tex. : 1979) · 2020Pooled it
- Cardiovascular benefits of air purifier in patients with stable coronary artery disease: A randomized single-blind crossover study.Frontiers in public health · 2022Trial
- Effects of the Use of Air Purifier on Indoor Environment and Respiratory System among Healthy Adults.International journal of environmental research and public health · 2020Trial
- HEPA filtration improves asthma control in children exposed to traffic-related airborne particles.Indoor air · 2020Trial
- Particulate matter exposure and health impacts of urban cyclists: a randomized crossover study.Environmental health : a global access science source · 2018Trial
- Effect of Portable Air Filtration Systems on Personal Exposure to Fine Particulate Matter and Blood Pressure Among Residents in a Low-Income Senior Facility: A Randomized Clinical Trial.JAMA internal medicine · 2018Trial
- Cardiopulmonary benefits of reducing indoor particles of outdoor origin: a randomized, double-blind crossover trial of air purifiers.Journal of the American College of Cardiology · 2015Trial
- The impacts of traffic-related and woodsmoke particulate matter on measures of cardiovascular health: a HEPA filter intervention study.Occupational and environmental medicine · 2015Trial
- Controlled exposure to particulate matter from urban street air is associated with decreased vasodilation and heart rate variability in overweight and older adults.Particle and fibre toxicology · 2015Trial
- Health Benefits of Air Purification: A Systematic Review.Environment & health (Washington, D.C.) · 2026Review
- Article
- Pathways of urban green space in shaping population aging across China via spatial spillover and non-linear threshold effects.BMC public health · 2026Article
- The impact of portable air cleaners on indoor particulate matter concentrations and perceptions of indoor air quality: a randomized crossover trial in three multifamily buildings.Journal of exposure science & environmental epidemiology · 2026Article
- Spatial spillovers and nonlinear effects of urban green space on population aging in China.Frontiers in public health · 2026Article
- Exposure to ambient air pollution and onset of Parkinson's disease in a large cohort study.NPJ Parkinson's disease · 2025Article
- The Association Between Indoor Air Pollutants and Brain Structure Indicators Using eTIV-Adjusted and Unadjusted Models: A Study in Seoul and Incheon.Brain sciences · 2025Article
- Article
- Inflammatory Cytokines and Chemokines Are Synergistically Induced in a ROS-Dependent Manner by a Co-Culture of Corneal Epithelial Cells and Neutrophil-like Cells in the Presence of Particulate Matter.Antioxidants (Basel, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExposure to particulate air pollution increases respiratory and cardiovascular morbidity and mortality, especially in elderly, possibly through inflammation and vascular dysfunction.
methodsWe examined potential beneficial effects of indoor air filtration in the homes of elderly, including people taking vasoactive drugs.Forty-eight nonsmoking subjects (51 to 81 years) in 27 homes were included in this randomized, double-blind, crossover intervention study with consecutive two-week periods with or without the inclusion of a high-efficiency particle air filter in re-circulating custom built units in their living room and bedroom. We measured blood pressure, microvascular and lung function and collected blood samples for hematological, inflammation, monocyte surface and lung cell damage markers before and at day 2, 7 and 14 during each exposure scenario.
resultsThe particle filters reduced the median concentration of PM2.5 from approximately 8 to 4 μg/m3 and the particle number concentration from 7669 to 5352 particles/cm3. No statistically significant effects of filtration as category were observed on microvascular and lung function or the biomarkers of systemic inflammation among all subjects, or in the subgroups taking (n = 11) or not taking vasoactive drugs (n = 37). However, the filtration efficacy was variable and microvascular function was within 2 days significantly increased with the actual PM2.5 decrease in the bedroom, especially among 25 subjects not taking any drugs.
conclusionSubstantial exposure contrasts in the bedroom and no confounding by drugs appear required for improved microvascular function by air filtration, whereas no other beneficial effect was found in this elderly population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.