ReviewJournal of biomechanics2014
Revolutionizing orthopaedic biomaterials: The potential of biodegradable and bioresorbable magnesium-based materials for functional tissue engineering.
Review in Journal of biomechanics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 213 citations in OpenAlex.
- Degradation of biodegradable orthopedic screws does (not) elevate tissue heating under Magnetic Resonance Imaging: Implications for next generation implants.Bioactive materials · 2026Article
- Advancements in biodegradable implants: evaluation in large animal surgical models.Annals of medicine and surgery (2012) · 2025Review
- Development of a Biodegradable Green Emitter Chitosan-Based OLED for Implantable Biomedical Devices.ACS applied materials & interfaces · 2025Article
- A Structural Optimization Framework for Biodegradable Magnesium Interference Screws.Biomimetics (Basel, Switzerland) · 2025Article
- Bone Defect Treatment in Regenerative Medicine: Exploring Natural and Synthetic Bone Substitutes.International journal of molecular sciences · 2025Review
- Challenges and Pitfalls of Research Designs Involving Magnesium-Based Biomaterials: An Overview.International journal of molecular sciences · 2024Review
- Fixation technique of biodegradable magnesium alloy suture anchor in the rotator cuff repair of the shoulder in a goat model: a technical note.BMC musculoskeletal disorders · 2024Article
- Prospective evaluation of ultrasound features of magnesium-based bioabsorbable screw resorption in pediatric fractures.European radiology · 2024Article
- Absorbable implants in sport medicine and arthroscopic surgery: A narrative review of recent development.Bioactive materials · 2024Review
- Comparison of Resorbable and Non-Resorbable Osteosynthesis Material in Hallux Surgery: A Systematic Review.Life (Basel, Switzerland) · 2023Review
- In vitro and in vivo study on fine-grained Mg-Zn-RE-Zr alloy as a biodegradeable orthopedic implant produced by friction stir processing.Bioactive materials · 2023Article
- Prospective Evaluation of Magnetic Resonance Imaging Features of Magnesium-Based Alloy Screw Resorption in Pediatric Fractures.Journal of clinical medicine · 2023Article
- High Complication Rate and High Percentage of Regressing Radiolucency in Magnesium Screw Fixation in 18 Consecutive Patients.Journal of personalized medicine · 2023Article
- Strategies for promoting tendon-bone healing: Current status and prospects.Frontiers in bioengineering and biotechnology · 2023Review
- Review
- Radiographic features of magnesium-based bioabsorbable screw resorption in paediatric fractures.Pediatric radiology · 2022Article
- Biocompatibility evaluation of peo-treated magnesium alloy implants placed in rabbit femur condyle notches and paravertebral muscles.Biomaterials research · 2022Article
- Review of the Effect of Surface Coating Modification on Magnesium Alloy Biocompatibility.Materials (Basel, Switzerland) · 2022Review
- Advances in Barrier Membranes for Guided Bone Regeneration Techniques.Frontiers in bioengineering and biotechnology · 2022Review
- The Biodegradability andFrontiers in bioengineering and biotechnology · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
In recent years, there has been a surge of interest in magnesium (Mg) and its alloys as biomaterials for orthopaedic applications, as they possess desirable mechanical properties, good biocompatibility, and biodegradability. Also shown to be osteoinductive, Mg-based materials could be particularly advantageous in functional tissue engineering to improve healing and serve as scaffolds for delivery of drugs, cells, and cytokines. In this paper, we will present two examples of Mg-based orthopaedic devices: an interference screw to accelerate ACL graft healing and a ring to aid in the healing of an injured ACL. In vitro tests using a robotic/UFS testing system showed that both devices could restore function of the goat stifle joint. Under a 67-N anterior tibial load, both the ACL graft fixed with the Mg-based interference screw and the Mg-based ring-repaired ACL could restore anterior tibial translation (ATT) to within 2mm and 5mm, respectively, of the intact joint at 30°, 60°, and 90° of flexion. In-situ forces in the replacement graft and Mg-based ring-repaired ACL were also similar to those of the intact ACL. Further, early in vivo data using the Mg-based interference screw showed that after 12 weeks, it was non-toxic and the joint stability and graft function reached similar levels as published data. Following these positive results, we will move forward in incorporating bioactive molecules and ECM bioscaffolds to these Mg-based biomaterials to test their potential for functional tissue engineering of musculoskeletal and other tissues.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.