ArticleMalaria journal2013
Clinical signs and symptoms cannot reliably predict Plasmodium falciparum malaria infection in pregnant women living in an area of high seasonal transmission.
Article in Malaria journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Age-modified factors associated with placental malaria in rural Burkina Faso.BMC pregnancy and childbirth · 2022Trial
- AQ-13, an investigational antimalarial, versus artemether plus lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria: a randomised, phase 2, non-inferiority clinical trial.The Lancet. Infectious diseases · 2017Trial
- Ex vivo anti-malarial drug susceptibility of Plasmodium falciparum isolates from pregnant women in an area of highly seasonal transmission in Burkina Faso.Malaria journal · 2015Trial
- Cytokine-Driven Immune Phenotypes at Delivery as Indicators of Malaria Infection Among Primigravidae in Burkina Faso: An Exploratory Analysis.Tropical medicine and infectious disease · 2026Article
- Prevalence and risk factors associated with infections caused by Plasmodium parasites at micro-geographic level in three villages of Muheza district in Tanga region, north-eastern Tanzania.Malaria journal · 2025Article
- Malaria and anaemia prevalence and associated factors among pregnant women initiating antenatal care in two regions in Ghana: an analytical cross-sectional study.BMC pregnancy and childbirth · 2025Article
- The Prevalence of Malaria Among Pregnant Women at a Tertiary Care Hospital in Somalia: A Cross-Sectional Study.BioMed research international · 2025Article
- Malaria diagnosis challenges andPathogens and global health · 2024Article
- Prevalence of clinical malaria and associated symptoms in pregnant women at Hamusit health center, Northwest Ethiopia.Heliyon · 2024Article
- Prevalence of Malaria Parasite among Pregnant Women Attending to Saudi Kassala Teaching Hospital in Kassala State, Eastern Sudan.Journal of tropical medicine · 2023Article
- Article
- Malaria and curable sexually transmitted and reproductive tract coinfection among pregnant women in rural Burkina Faso.Tropical medicine and health · 2021Article
- Asymptomatic malaria and anaemia among pregnant women during high and low malaria transmission seasons in Burkina Faso: household-based cross-sectional surveys in Burkina Faso, 2013 and 2017.Malaria journal · 2021Article
- Article
- Malaria prevalence in symptomatic and asymptomatic pregnant women in a high malaria-burden state in India.Tropical medicine and health · 2020Article
- [Malaria infection during pregnancy in Niamey, Niger].The Pan African medical journal · 2020Article
- Malaria in Pregnancy in Endemic Regions of Colombia: High Frequency of Asymptomatic and Peri-Urban Infections in Pregnant Women with Malaria.Infectious diseases in obstetrics and gynecology · 2020Article
- Review
- Interleukin-10 and soluble tumor necrosis factor receptor II are potential biomarkers ofBiomarker research · 2017Article
- Spatial heterogeneity can undermine the effectiveness of country-wide test and treat policy for malaria: a case study from Burkina Faso.Malaria journal · 2016Article
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMalaria in pregnancy is a major public health problem in endemic countries. Though the signs and symptoms of malaria among pregnant women have been already described, clinical presentation may vary according to intensity of transmission and local perceptions. Therefore, determining common signs and symptoms among pregnant women with a malaria infection may be extremely useful to identify those in need of further investigation by rapid diagnostic test or microscopy.
methodsSix hundred pregnant women attending the maternity clinic of Nanoro District Hospital, Burkina Faso were recruited, 200 with suspected clinical malaria and 400 as controls. Cases were matched with controls by gestational age and parity. Signs and symptoms were collected and a blood sample taken for rapid diagnostic test, microscopy and haemoglobin measurement. A multivariate model was used to assess the predictive value of signs and symptoms for malaria infection.
resultsThe overall prevalence of malaria was 42.6% (256/600) while anaemia was found in 60.8% (365/600) of the women. Nearly half (49%) of the cases and 39.5% of the controls had a malaria infection (p = 0.03). The most common signs and symptoms among the cases were fever (36%,72/200), history of fever (29%,58/200) and headache (52%,104/200). The positive predictive value for fever was 53% (95% CI:41-64), history of fever 58% (95% CI:37-63) and headache 51% (95% CI:41-61).
conclusionSigns and symptoms suggestive of malaria are frequent among pregnant women living in areas of intense transmission. Common malaria symptoms are not strong predictors of infection. For a better management of malaria in pregnancy, active screening to detect and treat malaria infection early should be performed on all pregnant women attending a health facility.
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