ArticleMalaria journal2013
Genotyping Plasmodium vivax isolates from the 2011 outbreak in Greece.
Article in Malaria journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed.
- Malaria in a metropolitan region of Southern Germany: past, present and future perspectives on a protozoan infection with the potential of re-appearance in Central Europe.Malaria journal · 2025Article
- Genetic Structure of IntroducedTropical medicine and infectious disease · 2024Article
- Investigation of an airport-associated cluster of falciparum malaria in Frankfurt, Germany, 2022.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024Article
- Influx of diverse, drug resistant and transmissible Plasmodium falciparum into a malaria-free setting in Qatar.BMC infectious diseases · 2020Article
- The Importance of an Active Case Detection (ACD) Programme for Malaria among Migrants from Malaria Endemic Countries: The Greek Experience in a Receptive and Vulnerable Area.International journal of environmental research and public health · 2020Article
- Population Genetics and Molecular Epidemiology of Eukaryotes.Microbiology spectrum · 2018Review
- Genetic Spatiotemporal Anatomy of Plasmodium vivax Malaria Episodes in Greece, 2009-2013.Emerging infectious diseases · 2018Article
- An outbreak of locally acquired Plasmodium vivax malaria among migrant workers in Oman.Parasite (Paris, France) · 2017Article
- Prevention of Malaria Resurgence in Greece through the Association of Mass Drug Administration (MDA) to Immigrants from Malaria-Endemic Regions and Standard Control Measures.PLoS neglected tropical diseases · 2015Article
- Neglected Plasmodium vivax malaria in northeastern States of India.The Indian journal of medical research · 2015Article
- Uncovering the transmission dynamics of Plasmodium vivax using population genetics.Pathogens and global health · 2015Review
- Plasmodium vivax populations are more genetically diverse and less structured than sympatric Plasmodium falciparum populations.PLoS neglected tropical diseases · 2015Article
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11 authors.
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Abstract
backgroundPlasmodium vivax malaria was common in Greece until the 1950s with epidemics involving thousands of cases every year. Greece was declared free of malaria by the World Health Organization in 1974. From 1974 to 2010, an average of 39 cases per year were reported, which were mainly imported. However, in 2009 and 2010 six and one autochthonous cases were reported culminating with a total of 40 autochthonous cases reported in 2011, of which 34 originated from a single region: Laconia of Southern Peloponnese. In this study the genotypic complexity of the P. vivax infections from the outbreak in Greece during 2011 is described, to elucidate the possible origin and spread of the disease.
methodsThree polymorphic markers of P. vivax were used; Pvmsp-3α and the microsatellites m1501 and m3502 on P. vivax isolates sampled from individuals diagnosed in Greece. Thirty-nine isolates were available for this study (20 autochthonous and 19 imported), mostly from Evrotas municipality in Laconia region, in southern Greece, (n = 29), with the remaining representing sporadic cases originating from other areas of Greece.
resultsGenotyping the Evrotas samples revealed seven different haplotypes where the majority of the P. vivax infections expressed two particular Pvmsp-3α-m1501-m3502 haplotypes, A10-128-151 (n = 14) and A10-121-142 (n = 7). These haplotypes appeared throughout the period in autochthonous and imported cases, indicating continuous transmission. In contrast, the P. vivax autochthonous cases from other parts of Greece were largely comprised of unique haplotypes, indicating limited transmission in these other areas.
conclusionsThe results indicate that several P. vivax strains were imported into various areas of Greece in 2011, thereby increasing the risk of re-introduction of malaria. In the region of Evrotas ongoing transmission occurred exemplifying that further control measures are urgently needed in this region of southern Europe. In circumstances where medical or travel history is scarce, methods of molecular epidemiology may prove highly useful for the correct classification of the cases.
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