ArticleBMC research notes2013
Autoimmune hypophysitis presenting with intracranial multi-organ involvement: three case reports and review of the literature.
Article in BMC research notes, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- IgG4-Related Disease of the Skull and Skull Base-A Systematic Review and Report of Two Cases.World neurosurgery · 2021Pooled it
- Seronegative Hypophysitis Presenting as Unilateral Lateral Rectus Palsy.Annals of Indian Academy of Neurology · 2026Article
- Carotid artery constriction in autoimmune hypophysitis: three case reports and literature review.Endocrine connections · 2025Review
- Secondary autoimmune hypothalamitis with severe memory impairment 7 years after the onset of diabetes insipidus due to lymphocytic hypophysitis: a case report.BMC neurology · 2022Article
- Preoperative differentiation of hypophysitis and pituitary adenomas using a novel clinicoradiologic scoring system.Pituitary · 2022Article
- IgG4-related hypophysitis.Endocrine · 2021Review
- Immunoglobulin G4-related disease of the cavernous sinus with orbit invasion - A case report.Surgical neurology international · 2021Article
- Successful management and treatment of SLE-associated hypophysitis.Immunologic research · 2020Article
- Clinical Characteristics of 76 Patients with IgG4-Related Hypophysitis: A Systematic Literature Review.International journal of endocrinology · 2019Review
- A case series of atypical features of patients with biopsy-proven isolated IgG4-related hypophysitis and normal serum IgG4 levels.Pituitary · 2018Article
- Infrequent organ involvement of IgG4-related diseases: a literature review.Clinical rheumatology · 2018Article
- Hypophyseal Involvement in Immunoglobulin G4-Related Disease: A Retrospective Study from a Single Tertiary Center.International journal of endocrinology · 2018Article
- IgG4-related hypophysitis is highly prevalent among cases of histologically confirmed hypophysitis.Brain pathology (Zurich, Switzerland) · 2017Article
- Review
- Revisitation of autoimmune hypophysitis: knowledge and uncertainties on pathophysiological and clinical aspects.Pituitary · 2016Review
- Clinical course of IgG4-related hypophysitis presenting with focal seizure and relapsing lymphocytic hypophysitis.BMC endocrine disorders · 2015Article
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5 authors.
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Abstract
backgroundAutoimmune hypophysitis very rarely spreads to nearby organs outside the pituitary tissue, for unknown reasons, with only 5 reported cases of hypophysitis spreading over the cavernous sinus. CASE PRESENTATION: Three patients presented with cases of non-infectious hypophysitis spreading outside the pituitary tissue over the cavernous sinus. All three cases were diagnosed with histological confirmation by transsphenoidal surgery, and the patients showed remarkable improvement with postoperative pulse dose steroid therapy, including disappearance of abnormal signal intensities in the bilateral hypothalami on magnetic resonance imaging, resolution of severe stenosis of the internal carotid artery, and normalization of swollen pituitary tissues. Two of 3 cases fulfilled the histological criteria of immunoglobulin G4-related disease, although none of the patients had high serum immunoglobulin G4 level.
conclusionThe true implications of such unusual spreading of hypophysitis to nearby organs are not fully understood, but the mechanism of occurrence might vary according to the timing of inflammation in this unusual mode of spreading. Pulse dose steroid therapy achieved remarkably good outcomes even in the patient with progressive severe stenosis of the internal carotid artery and rapid visual deterioration.
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