ArticleCardiovascular diabetology2013
Association between circulating leukocyte subtype counts and carotid intima-media thickness in Japanese subjects with type 2 diabetes.
Article in Cardiovascular diabetology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Toe-brachial index and toe systolic blood pressure for the diagnosis of peripheral arterial disease.The Cochrane database of systematic reviews · 2024Pooled it
- Mediterranean diet, neutrophil count, and carotid intima-media thickness in secondary prevention: the CORDIOPREV study.European heart journal · 2025Trial
- White blood cell count is not associated with flow-mediated vasodilation or nitroglycerine-induced vasodilation.Scientific reports · 2022Trial
- Absolute eosinophils count and the extent of coronary artery disease: a single centre cohort study.Journal of thrombosis and thrombolysis · 2015Trial
- Trial
- Fingertip skin autofluorescence as a non-invasive marker for vascular complications in patients with type 2 diabetes.Journal of diabetes investigation · 2025Article
- Triglyceride-glucose index in the associations between chronic low-grade inflammation and carotid intima-media thickness: mediation and effect-modification across triglyceride-glucose strata.BMC cardiovascular disorders · 2025Article
- The association between peripheral eosinophil count and chronic kidney disease: evidence from NHANES 1999-2018.Renal failure · 2024Article
- Association of Monocyte-to-HDL Cholesterol Ratio with Endothelial Dysfunction in Patients with Type 2 Diabetes.Journal of diabetes research · 2024Article
- Significance of Circulating Remnant Lipoprotein Cholesterol Levels Measured by Homogeneous Assay in Patients with Type 2 Diabetes.Biomolecules · 2023Article
- Pathogenesis and Clinical Significance of In-Stent Restenosis in Patients with Diabetes.International journal of environmental research and public health · 2021Review
- Monocyte-to-albumin ratio as a novel predictor of long-term adverse outcomes in patients after percutaneous coronary intervention.Bioscience reports · 2021Article
- Monocyte counts are negatively associated with ankle-brachial index values in non-dialysis-dependent chronic kidney disease patients.Renal failure · 2020Article
- Peripheral monocyte count is an independent predictor of all-cause mortality in type 2 diabetes with macro-vascular complications.Medicine · 2020Observational
- The Role of Monocyte to High-Density Lipoprotein Cholesterol Ratio in Prediction of Carotid Intima-Media Thickness in Patients With Type 2 Diabetes.Frontiers in endocrinology · 2019Article
- Association of lymphocyte to monocyte ratio with severity of coronary artery disease.Medicine · 2018Observational
- Increased maximum common carotid intima-media thickness is associated with smoking and hypertension in Tochigi Prefecture residents.Journal of medical ultrasonics (2001) · 2017Article
- Interaction between allergic asthma and atherosclerosis.Translational research : the journal of laboratory and clinical medicine · 2016Review
- The relationship between fasting plasma glucose and MPO in patients with acute coronary syndrome.BMC cardiovascular disorders · 2015Article
- [Leukocytes as risk markers for cardiovascular disease in adolescents: association with birth characteristics, nutritional status and biochemical tests].Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao PauloArticle
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn increased leukocyte count is an independent risk factor for cardiovascular events, but the association between leukocyte subtype counts and carotid atherosclerosis in patients with diabetes has not been determined. We therefore investigated the correlation between leukocyte subtype counts and intima-media thickness of the common carotid artery (CCA-IMT) in subjects with type 2 diabetes.
methodsThis cross-sectional study involved 484 in-patients with type 2 diabetes (282 males and 202 females), who were hospitalized for glycemic control and underwent carotid ultrasonography at Kumamoto University Hospital between 2005 and 2011. Mean and maximum CCA-IMT was measured by high-resolution B-mode ultrasonography.
resultsUnivariate analyses revealed that mean CCA-IMT was positively correlated with age, systolic blood pressure, brachial-ankle pulse wave velocity (PWV), urinary albumin excretion and duration of diabetes, but was negatively correlated with diastolic blood pressure and fasting plasma glucose. Maximum CCA-IMT was positively and negatively correlated with the same factors as mean CCA-IMT except for fasting plasma glucose. Mean CCA-IMT was positively correlated with total leukocyte (r = 0.124, p = 0.007), monocyte (r = 0.373, p < 0.001), neutrophil (r = 0.139, p = 0.002) and eosinophil (r = 0.107, p = 0.019) counts. Maximum CCA-IMT was positively correlated with total leukocyte (r = 0.154, p < 0.001), monocyte (r = 0.398, p < 0.001), neutrophil (r = 0.152, p < 0.001) and basophil counts (r = 0.102, p = 0.027). Multiple regression analyses showed that monocyte count, age and PWV were significant and independent factors associated with mean CCA-IMT (adjusted R2 = 0.239, p < 0.001), and that monocyte count, age and urinary albumin excretion were significant and independent factors associated with maximum CCA-IMT (adjusted R2 = 0.277, p < 0.001).
conclusionsMonocyte counts were positively correlated with both mean CCA-IMT and maximum CCA-IMT in patients with type 2 diabetes. Monocyte count may be a useful predictor of macrovascular complications in patients with type 2 diabetes.
trial registrationTrial registry no: UMIN000003526.
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