Evidence map›Paper›PMID 24373295›Full record

ArticleInfluenza and other respiratory viruses2014

Genetic variability of human metapneumo- and bocaviruses in children with respiratory tract infections.

Vasiliki Pogka, Afroditi Moutousi, Athanasios Kossyvakis, Antonios Kalliaropoulos, Dionyssios N Sgouras, Maria Giannaki, Andreas F Mentis

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Article in Influenza and other respiratory viruses, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Vasiliki PogkaNational Influenza Reference Laboratory of Southern Greece, Hellenic Pasteur Institute, Athens, Greece.
Afroditi Moutousi
Athanasios Kossyvakis
Antonios Kalliaropoulos
Dionyssios N Sgouras
Maria Giannaki
Andreas F Mentis
Pasteur Hellenic Institute · GRChildren's Hospital Agia Sophia · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe genotypic analysis of human metapneumo-(HMPV) and boca-(HBoV) viruses circulating in Greece and their comparison to reference and other clinical strains.

designGenetic analysis of representative strains over three consecutive winter seasons of the years 2005-2008.

settingRepresentative positive specimens for HMPV and HBoV from paediatric patients of healthcare units and hospitals in Southern Greece with influenza-like illness or other respiratory tract infections. SAMPLE: Seven to ten positive specimens for either HMPV or HBoV from each winter period. In total, 24 specimens positive for HMPV and 26 for HBoV, respectively.

main outcome measuresSequence diversity of HMPV and HBoV strains by sequencing the complete G and VP1/VP2 genes, respectively.

resultsIn total, 24 HMPV strains were found to have a 92-100% nucleotide and a 85.9-100% amino acid identity. Phylogenetic analysis based on the number of amino acid differences, revealed circulation of 4 different subclusters belonging to genetic lineage B2. Similarly, analysis of 26 HBoV strains indicated that 22 clustered within genotype St2, 2 into genotype St1 and the remaining 2 formed a third cluster derived from potential recombination between different St1 genotype strains. St2 HBoV genotype was observed throughout the whole observation period whereas St1 only during the second and the third winter period. Higher levels of heterogeneity were observed between HMPV compared to HBoV strains.

conclusionsPhylogenetic analysis revealed circulation of one single lineage (B2) for HMPV viruses and predominance of St2 genotype for HBoV viruses. A possible recombination between St1 genotype strains of HBoV was observed.

Indexed as

Genetic VariationAdolescentChildChild, PreschoolCluster AnalysisDNA, ViralFemaleGenotypeGreeceHuman bocavirusHumansInfantInfant, NewbornMaleMetapneumovirusMolecular EpidemiologyDNA, ViralRNA, ViralViral Structural ProteinsBocaviruschildrenmetapneumovirusphylogenetic analysisrespiratory viruses

Identifiers

PMID24373295
PMCPMC4177804
OpenAlexW1971732333

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.