ArticleInfluenza and other respiratory viruses2014
Clinical diagnosis of pandemic A(H1N1) 2009 influenza in children with negative rapid influenza diagnostic test by lymphopenia and lower C-reactive protein levels.
Article in Influenza and other respiratory viruses, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Influenza Virus Infects and Depletes Activated Adaptive Immune Responders.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Immunopathogenesis of Different Emerging Viral Infections: Evasion, Fatal Mechanism, and Prevention.Frontiers in immunology · 2021Review
- Risk factors and electrocardiogram characteristics for mortality in critical inpatients with COVID-19.Clinical cardiology · 2020Article
- Risk Factors and Clinical Determinants in Bronchiolitis of Infancy.Turkish thoracic journal · 2020Article
- Intravenous immunoglobulin fails to improve ARDS in patients undergoing ECMO therapy.Journal of intensive care · 2018Article
- Pneumonia, Acute Respiratory Distress Syndrome, and Early Immune-Modulator Therapy.International journal of molecular sciences · 2017Review
- Clinical characteristics of asthmatic patients with influenza-like illness and risk of severe exacerbations in Mexico.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2016Article
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8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe sensitivity of rapid influenza diagnostic test (RIDT) of children with influenza-like illness (ILI) remains low.
objectiveWe compare the parameters between pandemic A(H1N1) 2009 influenza with negative RIDT and ILI not H1N1 for improving the low sensitivity of RIDT for children with ILI.
methodsIn a cohort of consecutive laboratory-confirmed H1N1 influenza, we identified 150 H1N1 children with positive RIDT, 152 H1N1 children with negative RIDT, and 75 children with ILI not H1N1. Viral load in throat, complete blood count (CBC), and C-reactive protein (CRP) levels between H1N1 children with negative RIDT and children with ILI not H1N1 were assessed.
resultsThe diagnostic sensitivity of the RIDT was 45·5%. An analysis of CBC and CRP levels indicated that H1N1 children with negative RIDT had lower total leukocyte, neutrophil, lymphocyte, and basophil counts, and serum CRP levels (P < 0·01). Lymphocyte counts less than 1500 cells/mm(3) and CRP levels <15 mg/l, determined by a receiver operating characteristic curve, showed a diagnostic sensitivity of 52·5% and 80·7%, respectively. Combining the lymphocyte counts and CRP levels provided a diagnostic sensitivity of 91·5%. Moreover, H1N1 children with negative RIDT had a lower viral load than those with positive RIDT (3·33 versus 4·48 log10 copies/ml, P < 0·001); the viral load was negatively correlated to the lymphocyte count (P < 0·001).
conclusionsA combination of a low lymphocyte count and a low CRP level could, in the early disease phase, provide a useful screening for H1N1 children with false-negative RIDT, potentially facilitating differential diagnoses.
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