ArticleMolecular ecology2014
Inference of chromosomal inversion dynamics from Pool-Seq data in natural and laboratory populations of Drosophila melanogaster.
Article in Molecular ecology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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64 citing papers in PubMed.
- Early life-stage thermal resilience is determined by climate-linked regulatory variation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Putting Structural Variants Into Practice: The Role of Chromosomal Inversions in the Management of Marine Environments.Molecular ecology · 2025Review
- Beneficial reversal of dominance maintains a large-effect resistance polymorphism under fluctuating insecticide selection.Nature ecology & evolution · 2025Article
- Footprints of Worldwide Adaptation in Structured Populations of Drosophila melanogaster Through the Expanded DEST 2.0 Genomic Resource.Molecular biology and evolution · 2025Article
- The potential of inversions to accumulate balanced sexual antagonism is supported by simulations andeLife · 2025Article
- The Influence of Chromosomal Inversions on Genetic Variation and Clinal Patterns in Genomic Data of Drosophila melanogaster.Methods in molecular biology (Clifton, N.J.) · 2025Article
- From sub-Saharan Africa to China: Evolutionary history and adaptation ofScience advances · 2024Article
- Variation in mutation, recombination, and transposition rates inGenome research · 2023Article
- Patterns of Population Structure and Introgression Among Recently Differentiated Drosophila melanogaster Populations.Molecular biology and evolution · 2022Article
- Distinct signals of clinal and seasonal allele frequency change at eQTLs in Drosophila melanogaster.Evolution; international journal of organic evolution · 2022Article
- Pool-GWAS on reproductive dormancy in Drosophila simulans suggests a polygenic architecture.G3 (Bethesda, Md.) · 2022Article
- A Population Genomic Assessment of Three Decades of Evolution in a Natural Drosophila Population.Molecular biology and evolution · 2022Article
- Drosophila Evolution over Space and Time (DEST): A New Population Genomics Resource.Molecular biology and evolution · 2021Article
- Highly Parallel Genomic Selection Response in Replicated Drosophila melanogaster Populations with Reduced Genetic Variation.Genome biology and evolution · 2021Article
- The Genomic Architecture of Adaptation to Larval Malnutrition Points to a Trade-off with Adult Starvation Resistance in Drosophila.Molecular biology and evolution · 2021Article
- Detecting selected haplotype blocks in evolve and resequence experiments.Molecular ecology resources · 2021Article
- Demographic analyses of a new sample of haploid genomes from a Swedish population of Drosophila melanogaster.Scientific reports · 2020Article
- Genomic Analysis of European Drosophila melanogaster Populations Reveals Longitudinal Structure, Continent-Wide Selection, and Previously Unknown DNA Viruses.Molecular biology and evolution · 2020Article
- Evolutionary genomics can improve prediction of species' responses to climate change.Evolution letters · 2020Article
- Population Genomics on the Fly: Recent Advances in Drosophila.Methods in molecular biology (Clifton, N.J.) · 2020Review
4 more citing papers are in PubMed but not listed here.
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Abstract
Sequencing of pools of individuals (Pool-Seq) represents a reliable and cost-effective approach for estimating genome-wide SNP and transposable element insertion frequencies. However, Pool-Seq does not provide direct information on haplotypes so that, for example, obtaining inversion frequencies has not been possible until now. Here, we have developed a new set of diagnostic marker SNPs for seven cosmopolitan inversions in Drosophila melanogaster that can be used to infer inversion frequencies from Pool-Seq data. We applied our novel marker set to Pool-Seq data from an experimental evolution study and from North American and Australian latitudinal clines. In the experimental evolution data, we find evidence that positive selection has driven the frequencies of In(3R)C and In(3R)Mo to increase over time. In the clinal data, we confirm the existence of frequency clines for In(2L)t, In(3L)P and In(3R)Payne in both North America and Australia and detect a previously unknown latitudinal cline for In(3R)Mo in North America. The inversion markers developed here provide a versatile and robust tool for characterizing inversion frequencies and their dynamics in Pool-Seq data from diverse D. melanogaster populations.
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