ArticleBritish journal of clinical pharmacology2014
Prevalence, nature and potential preventability of adverse drug events - a population-based medical record study of 4970 adults.
Article in British journal of clinical pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Hospitalizations and deaths related to adverse drug events worldwide: Systematic review of studies with national coverage.European journal of clinical pharmacology · 2022Pooled it
- Health information management of older, multimorbid patients in German primary care: feasibility and first results of the outcome measures of a cluster-randomised controlled pilot trial - HYPERION-TransCare.BMC primary care · 2025Trial
- Trial
- Association between unresolved drug-related problems and 6-month hospital readmissions following pharmacist-led medication reviews: a retrospective observational study.International journal of clinical pharmacy · 2026Observational
- Drug-Event Pairs as Indicators for the Detection of Adverse Drug Reactions during Hospitalization in Routinely Collected Electronic Data Sources.Clinical pharmacology and therapeutics · 2025Article
- Adverse drug reactions and associated patient characteristics in older community-dwelling adults: a 6-year prospective cohort study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2023Article
- Incidence and preventability of hospital admissions for adverse drug reactions in France: A prospective observational study (IATROSTAT).British journal of clinical pharmacology · 2023Observational
- Healthcare costs of adverse drug reactions and potentially inappropriate prescribing in older adults: a population-based study.BMJ open · 2022Article
- Characterising older adults' risk of harm from blood-pressure lowering medications: a sub-analysis from the PRIME study.Age and ageing · 2022Article
- Optimizing Clinical Monitoring Tools to Enhance Patient Review by Pharmacists.Applied clinical informatics · 2021Article
- A population-based study of self-reported adverse drug events among Lebanese outpatients.Scientific reports · 2021Observational
- Medication-related harm in older adults following hospital discharge: development and validation of a prediction tool.BMJ quality & safety · 2020Article
- Adverse drug reactions in primary care: a scoping review.BMC health services research · 2020Article
- Creating an Interprofessional guideline to support patients receiving oral anticoagulation therapy: a Delphi exercise.International journal of clinical pharmacy · 2019Article
- Sex differences in adverse drug reactions reported to the National Pharmacovigilance Centre in the Netherlands: An explorative observational study.British journal of clinical pharmacology · 2019Observational
- Clinical relevance of alerts from a decision support system, PHARAO, for drug safety assessment in the older adults.BMC geriatrics · 2019Article
- Medication Errors Associated With Adverse Drug Reactions in Iran (2015-2017): A P-Method Approach.International journal of health policy and management · 2018Article
- Can doctors identify older patients at risk of medication harm following hospital discharge? A multicentre prospective study in the UK.British journal of clinical pharmacology · 2018Article
- Patterns of adverse drug reaction signals in NAFDAC pharmacovigilance activities from January to June 2015: safety of drug use in Nigeria.Pharmacology research & perspectives · 2018Article
- Effect of a voice recognition system on pediatric outpatient medication errors at a tertiary healthcare facility in Kenya.Therapeutic advances in drug safety · 2018Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo estimate the 3 month prevalence of adverse drug events (ADEs), categories of ADEs and preventable ADEs, and the preventability of ADEs among adults in Sweden. Further, to identify drug classes and organ systems associated with ADEs and estimate their seriousness.
methodsA random sample of 5025 adults in a Swedish county council in 2008 was drawn from the Total Population Register. All their medical records in 29 inpatient care departments in three hospitals, 110 specialized outpatient clinics and 51 primary care units were reviewed retrospectively in a stepwise manner, and complemented with register data on dispensed drugs. ADEs, including adverse drug reactions (ADRs), sub-therapeutic effects of drug therapy (STEs), drug dependence and abuse, drug intoxications from overdose, and morbidities due to drug-related untreated indication, were detected during a 3 month study period, and assessed for preventability.
resultsAmong 4970 included individuals, the prevalence of ADEs was 12.0% (95% confidence interval (CI) 11.1, 12.9%), and preventable ADEs 5.6% (95% CI 5.0, 6.2%). ADRs (6.9%; 95% CI 6.2, 7.6%) and STEs (6.4%; 95% CI 5.8, 7.1%) were more prevalent than the other ADEs. Of the ADEs, 38.8% (95% CI 35.8-41.9%) was preventable, varying by ADE category and seriousness. ADEs were frequently associated with nervous system and cardiovascular drugs, but the associated drugs and affected organs varied by ADE category.
conclusionsThe considerable burden of ADEs and preventable ADEs from commonly used drugs across care settings warrants large-scale efforts to redesign safer, higher quality healthcare systems. The heterogeneous nature of the ADE categories should be considered in research and clinical practice for preventing, detecting and mitigating ADEs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.