Evidence map›Paper›PMID 24372231›Full record

ReviewCurrent pharmaceutical biotechnology2013

Ultrasound and microbubble guided drug delivery: mechanistic understanding and clinical implications.

Wang Tzu-Yin, Katheryne E Wilson, Steven Machtaler, Jurgen K Willmann

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current pharmaceutical biotechnology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed.

  1. Trial
  2. Acoustically Activatable Drug-Loaded Nanodroplets for Mechanochemical Therapy in Solid Tumors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Wang Tzu-Yin
Katheryne E Wilson
Steven Machtaler
Jurgen K WillmannDepartment of Radiology and Molecular Imaging Program at Stanford, School of Medicine, Stanford University, 300 Pasteur Drive, Room H1307, Stanford, CA 94305-5621, USA. willmann@stanford.edu.

Funding

Stanford Molecular Imaging Scholars - SMISR25CA118681 · NCI · STANFORD UNIVERSITY · PI LEVIN, CRAIG S · 2006 to 2015
$5.0M
Quantification and monitoring inflammation in IBD with Molecular UltrasoundR01DK092509 · NIDDK · STANFORD UNIVERSITY · PI HARGREAVES, BRIAN ANDREW · 2012 to 2016
$2.4M
Molecular Ultrasound for Early Breast Cancer DetectionR01CA155289 · NCI · STANFORD UNIVERSITY · PI WILLMANN, JUERGEN KARL · 2011 to 2015
$1.6M
NCI NIH HHS R01 CA155289NCI NIH HHS R01 CA155289-01A1NCI NIH HHS R25 CA118681NIDDK NIH HHS R01 DK092509NIDDK NIH HHS R01 DK092509-01A1
6 · The paper itself

Abstract

Ultrasound mediated drug delivery using microbubbles is a safe and noninvasive approach for spatially localized drug administration. This approach can create temporary and reversible openings on cellular membranes and vessel walls (a process called "sonoporation"), allowing for enhanced transport of therapeutic agents across these natural barriers. It is generally believed that the sonoporation process is highly associated with the energetic cavitation activities (volumetric expansion, contraction, fragmentation, and collapse) of the microbubble. However, a thorough understanding of the process was unavailable until recently. Important progress on the mechanistic understanding of sonoporation and the corresponding physiological responses in vitro and in vivo has been made. Specifically, recent research shed light on the cavitation process of microbubbles and fluid motion during insonation of ultrasound, on the spatio-temporal interactions between microbubbles and cells or vessel walls, as well as on the temporal course of the subsequent biological effects. These findings have significant clinical implications on the development of optimal treatment strategies for effective drug delivery. In this article, current progress in the mechanistic understanding of ultrasound and microbubble mediated drug delivery and its implications for clinical translation is discussed.

Indexed as

Drug Delivery SystemsAnimalsContrast MediaMicrobubblesUltrasonicsContrast Media

Identifiers

PMID24372231
PMCPMC4084724

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.