Evidence map›Paper›PMID 24371583›Full record

ArticleResults in immunology2012

Circulating interleukin-8 and plasminogen activator inhibitor-1 are increased in women with ovarian carcinoma.

Guro Aune, Astrid Kamilla Stunes, Aina-Mari Lian, Janne Elin Reseland, Solveig Tingulstad, Sverre H Torp, Unni Syversen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Results in immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. The Emerging Role of Adiponectin in Female Malignancies.International journal of molecular sciences · 2019
    Review
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Guro AuneDepartment of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian, University of Science and Technology (NTNU), Trondheim, Norway.
Astrid Kamilla StunesDepartment of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian, University of Science and Technology (NTNU), Trondheim, Norway.
Aina-Mari LianDepartment of Biomaterials, Institute for Clinical Dentistry, University of Oslo (UiO), Oslo, Norway.
Janne Elin ReselandDepartment of Biomaterials, Institute for Clinical Dentistry, University of Oslo (UiO), Oslo, Norway.
Solveig TingulstadDepartment of Gynecological Oncology, Department of Laboratory Medicine, Children's and Women's Health, St. Olav's University Hospital, Trondheim, Norway.
Sverre H TorpDepartment of Pathology and Medical Genetics, Department of Laboratory Medicine, Children's and Women's Health, St. Olav's University Hospital, Trondheim, Norway.
Unni SyversenDepartment of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian, University of Science and Technology (NTNU), Trondheim, Norway ; Department of Endocrinology, St. Olav's University Hospital, Trondheim, Norway.
St Olav's University Hospital · NONorwegian University of Science and Technology · NOUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Elevated serum levels of several cytokines have been reported in ovarian cancer. We have previously found a diagnostic and prognostic value of hepatocyte growth factor (HGF). The aims of this study were to evaluate the diagnostic and prognostic value of multiple serum cytokines in women with ovarian tumors, and to examine possible associations between serum levels of cytokines and the previously analyzed HGF. Preoperative levels of multiple cytokines were quantified by serum-based immunoassays in 113 women with a pelvic mass: 57 carcinomas, 23 borderline tumors, and 33 benign ovarian tumors. The results were related to clinicopathological parameters. Univariate and multivariate analyses of five-year overall survival were performed. The women with ovarian carcinoma had significantly higher preoperative serum levels of cancer antigen 125 (CA 125), interleukin 8 (IL-8), and plasminogen activator inhibitor-1 (PAI-1) than women with benign ovarian tumors. Serum IL-8 and PAI-1 levels were positively correlated to serum levels of HGF. In a multivariate analysis of five-year overall survival, IL-8 had a prognostic impact. Serum levels of IL-8 and PAI-1 were elevated in women with ovarian carcinoma compared to women with benign ovarian tumors, and positively correlated to serum HGF levels in women with ovarian tumors. IL-8 also seemed to have a prognostic impact.

Indexed as

Hepatocyte growth factorInterleukin-8Ovarian cancerPlasma markersPlasminogen activator inhibitor-1

Identifiers

PMID24371583
PMCPMC3862343
OpenAlexW2001477900

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.