ArticleResults in immunology2012
Leukocyte transcriptome from chickens infected with avian pathogenic Escherichia coli identifies pathways associated with resistance.
Article in Results in immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Chicken heterophils as evolutionary models: insights into myeloperoxidase-independent antimicrobial strategies.Frontiers in immunology · 2026Review
- Differential responses to avian pathogenicFrontiers in cellular and infection microbiology · 2024Article
- Aerosol vaccination of chicken pullets with irradiated avian pathogenicFrontiers in immunology · 2023Article
- Implementing real-time immunometabolic assays and immune cell profiling to evaluate systemic immune response variations toFrontiers in veterinary science · 2023Article
- Analysis of miRNA Expression Profiling ofInternational journal of molecular sciences · 2022Article
- Transcriptomic Analysis of the Spleen of Different Chicken Breeds Revealed the Differential Resistance ofGenes · 2022Article
- Transcriptional Regulation ofInternational journal of molecular sciences · 2022Article
- Analysis of circRNA expression in chicken HD11 cells in response to avian pathogenicFrontiers in veterinary science · 2022Article
- Genetic responses of inbred chicken lines illustrate importance of eIF2 family and immune-related genes in resistance to Newcastle disease virus.Scientific reports · 2020Article
- Dynamic Interplay of Host and Pathogens in an Avian Whole-Blood Model.Frontiers in immunology · 2020Article
- Concordant expression pattern across multiple immune tissues of commercial broilers in response to avian pathogenic3 Biotech · 2019Article
- RNA-seq profiles of chicken type II pneumocyte in response to Escherichia coli infection.PloS one · 2019Article
- Avian PathogenicFrontiers in immunology · 2019Article
- Messenger RNA Sequencing and Pathway Analysis Provide Novel Insights Into the Susceptibility toFrontiers in genetics · 2018Article
- A recombinant multi-antigen vaccine with broad protection potential against avian pathogenic Escherichia coli.PloS one · 2017Article
- Novel MicroRNA Involved in Host Response to Avian Pathogenic Escherichia coli Identified by Deep Sequencing and Integration Analysis.Infection and immunity · 2017Article
- Thymus transcriptome reveals novel pathways in response to avian pathogenic Escherichia coli infection.Poultry science · 2016Article
- Expression of Inflammatory and Cell Death Program Genes and Comet DNA Damage Assay Induced by Escherichia coli in Layer Hens.PloS one · 2016Article
- Avian pathogenic Escherichia coli (APEC) infection alters bone marrow transcriptome in chickens.BMC genomics · 2015Article
- Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Avian pathogenic Escherichia coli (APEC) causes colibacillosis, which is responsible for morbidity and mortality in chickens. Gene expression patterns have previously been demonstrated to differ between chicken populations that are resistant vs. susceptible to bacterial infection, but little is currently known about gene expression response to APEC. Increased understanding of gene expression patterns associated with resistance will facilitate genetic selection to increase resistance to APEC. Male broiler chicks were vaccinated at 2 weeks of age and challenged with APEC at 4 weeks of age. Peripheral blood leukocytes were collected at 1 and 5 day post-infection. Lesions on the liver, pericardium, and air sacs were used to assign a mild or severe pathology status to non-vaccinated, challenged chicks. Ten treatment groups were therefore generated with a priori factors of vaccination, challenge, day post-infection, and the a posteriori factor of pathology status. Global transcriptomic response was evaluated using the Agilent 44K chicken microarray. APEC infection resulted in more up-regulation than down-regulation of differentially expressed genes. Immune response and metabolic processes were enriched with differentially expressed genes. Although vaccination significantly reduced lesions in challenged bird, there was no detectable effect of vaccination on gene expression. This study investigated the transcriptomic differences in host responses associated with mild vs. severe pathology, in addition to the effects of vaccination and challenge, thus revealing genes and networks associated with response to APEC and providing a foundation for future studies on, and genetic selection for, genetic resistance to APEC.
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