ArticleJournal of nutrition & food sciences2012
Buffer Therapy for Cancer.
Article in Journal of nutrition & food sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Exploring the Potential Use of Natural Products Together with Alkalization in Cancer Therapy.Pharmaceutics · 2024Review
- Amorphous Calcium Carbonate Shows Anti-Cancer Properties That are Attributed to Its Buffering Capacity.Cancers · 2023Article
- Metabolomics and the Multi-Omics View of Cancer.Metabolites · 2022Review
- Back to basic: Trials and tribulations of alkalizing agents in cancer.Frontiers in oncology · 2022Article
- What do cellular responses to acidity tell us about cancer?Cancer metastasis reviews · 2021Review
- Glioma stem cells and their roles within the hypoxic tumor microenvironment.Theranostics · 2021Review
- Acidosis and cancer: from mechanism to neutralization.Cancer metastasis reviews · 2019Review
- Targeting acidity in cancer and diabetes.Biochimica et biophysica acta. Reviews on cancer · 2019Review
- Concurrent Longitudinal EPR Monitoring of Tissue Oxygenation, Acidosis, and Reducing Capacity in Mouse Xenograft Tumor Models.Cell biochemistry and biophysics · 2017Article
- Effect of Modified Alkaline Supplementation on Syngenic Melanoma Growth in CB57/BL Mice.PloS one · 2016Article
- Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane.Nature communications · 2015Article
- Mechanisms of buffer therapy resistance.Neoplasia (New York, N.Y.) · 2014Article
- Involvement of tumor macrophage HIFs in chemotherapy effectiveness: mathematical modeling of oxygen, pH, and glutathione.PloS one · 2014Article
- Membrane Partitioning of TEMPO Discriminates Human Lung Cancer from Neighboring Normal Cells.Acta naturaeArticle
- Metabolism and its sequelae in cancer evolution and therapy.Cancer journal (Sudbury, Mass.)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Oral administration of pH buffers can reduce the development of spontaneous and experimental metastases in mice, and has been proposed in clinical trials. Effectiveness of buffer therapy is likely to be affected by diet, which could contribute or interfere with the therapeutic alkalinizing effect. Little data on food pH buffering capacity was available. This study evaluated the pH and buffering capacity of different foods to guide prospective trials and test the effect of the same buffer (lysine) at two different ionization states. Food groups were derived from the Harvard Food Frequency Questionnaire. Foods were blended and pH titrated with acid from initial pH values until 4.0 to determine "buffering score", in mmol H
Indexed as
Identifiers
24371544PMC3872072W1995692207What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.