ArticleAnnals of dermatology2013
Clinical and histological correlation in post-burn hypertrophic scar for pain and itching sensation.
Article in Annals of dermatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Interventions for postburn pruritus.The Cochrane database of systematic reviews · 2024Pooled it
- Epidemiological Trends and Clinical Implications: An 8-Year Retrospective Study from a Burn Rehabilitation Center in Taiwan.Medicina (Kaunas, Lithuania) · 2026Article
- Article
- Cellular and molecular changes in the skin driving increased nociception and pain during burn injury and repair.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Deciphering the cellular landscape of pathological scars.Burns & trauma · 2026Article
- Mechanisms of extracorporeal shock wave therapy in burn scar repair: Advances in immunoactivation-based scar remodeling research.Regenerative therapy · 2025Review
- Subcutaneous Injection and Brush Application of Ovalbumin-Aluminum Salt Solution Induces Dermatitis-like Changes in Mice.Journal of clinical medicine · 2025Article
- Heart Rate Variability Subsequent to Auriculotherapy Among Individuals Afflicted by Major Burn Scars.Annals of plastic surgery · 2025Article
- [Research advances on the mechanism and treatment of post-burn pruritus].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2023Review
- Healing Mechanisms in Cutaneous Wounds: Tipping the Balance.Tissue engineering. Part B, Reviews · 2022Review
- Effect of extracorporeal shock wave therapy on keratinocytes derived from human hypertrophic scars.Scientific reports · 2021Article
- Long Term Outcome After Open Abdomen Treatment: Function and Quality of Life.Frontiers in surgery · 2021Article
- A Review of the Evidence for and against a Role for Mast Cells in Cutaneous Scarring and Fibrosis.International journal of molecular sciences · 2020Review
- Novel Analgesics with Peripheral Targets.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Review
- Post-Burn Pruritus.International journal of molecular sciences · 2020Review
- Mast Cells in Skin Scarring: A Review of Animal and Human Research.Frontiers in immunology · 2020Article
- Dorsal pentagonal island flap to reconstruct post-burn interdigital web.Annals of the Royal College of Surgeons of England · 2019Article
- Article
- Interleukin-31, Interleukin-31RA, and OSMR Expression Levels in Post-burn Hypertrophic Scars.Journal of pathology and translational medicine · 2018Article
- Efficacy of Topical Enalapril in Treatment of Hypertrophic Scars.World journal of plastic surgery · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypertrophic scar following a burn is caused by the excessive deposit of collagen resulting in an exaggerated wound healing response. The burn patient complains of pain and itching over the scar, which can give rise to cosmetic and functional problems.
objectiveThe aim of this study was to investigate the clinical and histological correlation of a hypertrophic burn scar for itching and pain sensations.
methodsThirty-eight patients underwent a scar release and skin graft. the modified Vancouver scar scale and the verbal numerical rating scale were recorded. All biopsies were taken from scar tissue (scar) and normal tissue (normal). Histologically, tissues were observed in the epidermis, the monocytes around the vessels, the collagen fiber, elastic fiber, and the mast cells.
resultsThe mean total score of MVSS was 8.4±2.7 (pliability 2.0±0.9; thickness 1.8±0.9; vascularity 2.0± 0.9; and pigmentation 2.1±0.9). Pain and itching were 2.4±2.0 and 2.9±3.0. Epidermis were 7.9±2.8 layers (scar) and 4.0±0.8 layers (normal). The collagen fibers were thin and dense (scar) and thicker and loose (normal). The elastic fibers were thin and nonexistent (scar) and thin and loose (normal). Mast cells were 11.2±5.8/high power field (scar) and 7.4±4.1 (normal).
conclusionAs the scar tissue thickens, the itching becomes more severe. The stiffness of the scar with the pain appeared to be associated with the condition of the tissue. The correlation between clinical and histological post-burn hypertrophic scars will help further studies on the scar. This helped with the development of the base material for therapeutic strategies.
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