ArticleJournal of neurophysiology2014
Modeling activity-dependent changes of axonal spike conduction in primary afferent C-nociceptors.
Article in Journal of neurophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
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Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- Mathematical and Computational Models for Pain: A Systematic Review.Pain medicine (Malden, Mass.) · 2021Pooled it
- Modelling the memory of unmyelinated axons: Integration of a data-driven approach with physiological memory concept.The Journal of physiology · 2026Article
- Methylglyoxal alters C-fibre activity-dependent slowing and induces heat hyperalgesia in a sex-dependent manner, in rats.Pain reports · 2026Article
- The optimization of neuroprosthetic interfaces relying on biophysical and surrogate digital twins.npj biomedical innovations · 2026Review
- Shaping the Action Potential in Dorsal Root and Trigeminal Ganglia Neurons: Relevance to Pain Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- A nociceptor excitability test for identifying alterations of the Nav1.7 channels in humans.Pain · 2026Article
- PyFibers: An open-source NEURON-Python package to simulate responses of model nerve fibers to electrical stimulation.PLoS computational biology · 2025Article
- In Silico analysis of concentration and spatial distribution effects of magnetoelectric nanoparticles on peripheral nerve activation.Bioelectronic medicine · 2025Article
- Scaling of vagus nerve stimulation parameters does not achieve equivalent nerve responses across species.Bioelectronic medicine · 2025Article
- Nociceptor sodium channels shape subthreshold phase, upstroke, and shoulder of action potentials.The Journal of general physiology · 2025Article
- Article
- Arbor-TVB: a novel multi-scale co-simulation framework with a case study on neural-level seizure generation and whole-brain propagation.Frontiers in computational neuroscience · 2025Article
- A Computational Framework for Understanding the Impact of Prior Experiences on Pain Perception and Neuropathic Pain.PLoS computational biology · 2024Article
- Reverse-engineered models reveal differential membrane properties of autonomic and cutaneous unmyelinated fibers.PLoS computational biology · 2024Article
- Towards enhanced functionality of vagus neuroprostheses through in silico optimized stimulation.Nature communications · 2024Article
- NRV: An open framework for in silico evaluation of peripheral nerve electrical stimulation strategies.PLoS computational biology · 2024Article
- Computational models of compound nerve action potentials: Efficient filter-based methods to quantify effects of tissue conductivities, conduction distance, and nerve fiber parameters.PLoS computational biology · 2024Article
- NRV: An open framework forbioRxiv : the preprint server for biology · 2024Article
- Depolarization of mouse DRG neurons by GABA does not translate into acute pain or hyperalgesia in healthy human volunteers.PloS one · 2024Article
- Blocking Aδ- and C-fiber neural transmission by sub-kilohertz peripheral nerve stimulation.Frontiers in neuroscience · 2024Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Action potential initiation and conduction along peripheral axons is a dynamic process that displays pronounced activity dependence. In patients with neuropathic pain, differences in the modulation of axonal conduction velocity by activity suggest that this property may provide insight into some of the pathomechanisms. To date, direct recordings of axonal membrane potential have been hampered by the small diameter of the fibers. We have therefore adopted an alternative approach to examine the basis of activity-dependent changes in axonal conduction by constructing a comprehensive mathematical model of human cutaneous C-fibers. Our model reproduced axonal spike propagation at a velocity of 0.69 m/s commensurate with recordings from human C-nociceptors. Activity-dependent slowing (ADS) of axonal propagation velocity was adequately simulated by the model. Interestingly, the property most readily associated with ADS was an increase in the concentration of intra-axonal sodium. This affected the driving potential of sodium currents, thereby producing latency changes comparable to those observed for experimental ADS. The model also adequately reproduced post-action potential excitability changes (i.e., recovery cycles) observed in vivo. We performed a series of control experiments replicating blockade of particular ion channels as well as changing temperature and extracellular ion concentrations. In the absence of direct experimental approaches, the model allows specific hypotheses to be formulated regarding the mechanisms underlying activity-dependent changes in C-fiber conduction. Because ADS might functionally act as a negative feedback to limit trains of nociceptor activity, we envisage that identifying its mechanisms may also direct efforts aimed at alleviating neuronal hyperexcitability in pain patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.