ArticleJournal of neurophysiology2014
Locomotor impact of beneficial or nonbeneficial H-reflex conditioning after spinal cord injury.
Article in Journal of neurophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 26 citations in OpenAlex.
- Neurorehabilitation in the 21st Century: New Science, New Strategies, New Expectations.Neurorehabilitation and neural repair · 2026Review
- Biomarkers for rapid H-reflex operant conditioning among females.Journal of neurophysiology · 2023Article
- Enhancing neurorehabilitation by targeting beneficial plasticity.Frontiers in rehabilitation sciences · 2023Review
- The Evoked Potential Operant Conditioning System (EPOCS): A Research Tool and an Emerging Therapy for Chronic Neuromuscular Disorders.Journal of visualized experiments : JoVE · 2022Article
- Heksor: the central nervous system substrate of an adaptive behaviour.The Journal of physiology · 2022Article
- H-reflex conditioning during locomotion in people with spinal cord injury.The Journal of physiology · 2021Article
- Repeated and patterned stimulation of cutaneous reflex pathways amplifies spinal cord excitability.Journal of neurophysiology · 2020Article
- Can Operant Conditioning of EMG-Evoked Responses Help to Target Corticospinal Plasticity for Improving Motor Function in People With Multiple Sclerosis?Frontiers in neurology · 2020Review
- Acquisition of a simple motor skill: task-dependent adaptation and long-term changes in the human soleus stretch reflex.Journal of neurophysiology · 2019Article
- Operant conditioning of the motor-evoked potential and locomotion in people with and without chronic incomplete spinal cord injury.Journal of neurophysiology · 2019Article
- The negotiated equilibrium model of spinal cord function.The Journal of physiology · 2018Review
- Retraining Reflexes: Clinical Translation of Spinal Reflex Operant Conditioning.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018Review
- Acquisition, Maintenance, and Therapeutic Use of a Simple Motor Skill.Current opinion in behavioral sciences · 2018Article
- Why New Spinal Cord Plasticity Does Not Disrupt Old Motor Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Efficient neuroplasticity induction in chronic stroke patients by an associative brain-computer interface.Journal of neurophysiology · 2016Article
- Ablation of the inferior olive prevents H-reflex down-conditioning in rats.Journal of neurophysiology · 2016Article
- Spinal interneurons and forelimb plasticity after incomplete cervical spinal cord injury in adult rats.Journal of neurotrauma · 2015Article
- Restoring walking after spinal cord injury: operant conditioning of spinal reflexes can help.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2015Review
- Targeted neuroplasticity for rehabilitation.Progress in brain research · 2015Review
- Persistent beneficial impact of H-reflex conditioning in spinal cord-injured rats.Journal of neurophysiology · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
When new motor learning changes neurons and synapses in the spinal cord, it may affect previously learned behaviors that depend on the same spinal neurons and synapses. To explore these effects, we used operant conditioning to strengthen or weaken the right soleus H-reflex pathway in rats in which a right spinal cord contusion had impaired locomotion. When up-conditioning increased the H-reflex, locomotion improved. Steps became longer, and step-cycle asymmetry (i.e., limping) disappeared. In contrast, when down-conditioning decreased the H-reflex, locomotion did not worsen. Steps did not become shorter, and asymmetry did not increase. Electromyographic and kinematic analyses explained how H-reflex increase improved locomotion and why H-reflex decrease did not further impair it. Although the impact of up-conditioning or down-conditioning on the H-reflex pathway was still present during locomotion, only up-conditioning affected the soleus locomotor burst. Additionally, compensatory plasticity apparently prevented the weaker H-reflex pathway caused by down-conditioning from weakening the locomotor burst and further impairing locomotion. The results support the hypothesis that the state of the spinal cord is a "negotiated equilibrium" that serves all the behaviors that depend on it. When new learning changes the spinal cord, old behaviors undergo concurrent relearning that preserves or improves their key features. Thus, if an old behavior has been impaired by trauma or disease, spinal reflex conditioning, by changing a specific pathway and triggering a new negotiation, may enable recovery beyond that achieved simply by practicing the old behavior. Spinal reflex conditioning protocols might complement other neurorehabilitation methods and enhance recovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.