ArticleClinical and vaccine immunology : CVI2014
Estimates of mumps seroprevalence may be influenced by antibody specificity and serologic method.
Article in Clinical and vaccine immunology : CVI, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Immunogenicity and safety of the new MMR vaccine containing measles AIK-C, rubella Takahashi, and mumps RIT4385 strains in Japanese children: a randomized phase I/II clinical trial.Human vaccines & immunotherapeutics · 2019Trial
- Seroprotection Against Mumps in MMR Vaccinated Children Aged 9-12 Years: A Cross-Sectional Study.Indian pediatrics · 2026Article
- Age- and Sex-Dependent Heterogeneity in Mumps Virus Immunity Among US Blood Donors Born Between 1928-1993.The Journal of infectious diseases · 2026Article
- Article
- The High Seropositivity of Mumps Virus IgG Antibodies among School-Aged Children in Rural Areas of the Mbarali District in the Mbeya Region, Tanzania: It Is High Time for Consideration in the National Immunization Program.Children (Basel, Switzerland) · 2024Article
- Immunogenicity of Mumps Virus Genotype G Vaccine Candidates in Jeryl Lynn-Immunized Mice.Journal of virology · 2022Article
- Mumps Outbreaks in Vaccinated Populations-Is It Time to Re-assess the Clinical Efficacy of Vaccines?Frontiers in immunology · 2020Review
- Assessment of Mumps Virus-Specific Antibodies: Comparison of Plaque Reduction Neutralization Test and Enzyme-Linked Immunosorbent Assay Estimates.The Journal of infectious diseases · 2019Article
- Decreased humoral immunity to mumps in young adults immunized with MMR vaccine in childhood.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Differential durability of immune responses to measles and mumps following MMR vaccination.Vaccine · 2019Article
- The Human CD4Journal of virology · 2019Article
- Article
- Immunogenicity of mumps virus vaccine candidates matching circulating genotypes in the United States and China.Vaccine · 2017Article
- Mumps Virus Nucleoprotein and Hemagglutinin-Specific Antibody Response Following a Third Dose of Measles Mumps Rubella Vaccine.Open forum infectious diseases · 2017Article
- Immunoproteomic Profiling of Antiviral Antibodies in New-Onset Type 1 Diabetes Using Protein Arrays.Diabetes · 2016Article
- Remembering mumps.PLoS pathogens · 2015Review
- Resurgence of mumps in Korea.Infection & chemotherapy · 2015Review
- Factors influencing preclinical in vivo evaluation of mumps vaccine strain immunogenicity.Human vaccines & immunotherapeutics · 2015Article
- Dynamics of the serologic response in vaccinated and unvaccinated mumps cases during an epidemic.Human vaccines & immunotherapeutics · 2015Observational
- Mumps serum antibody levels before and after an outbreak to assess infection and immunity in vaccinated students.Open forum infectious diseases · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neutralizing antibodies are assumed to be essential for protection against mumps virus infection, but their measurement is labor- and time-intensive. For this reason, enzyme-linked immunosorbent assays (ELISAs) are typically used to measure mumps-specific IgG levels. However, since there is poor correlation between mumps neutralization titers and ELISAs that measure the presence of mumps-specific IgG levels, ELISAs that better correlate with neutralization are needed. To address this issue, we measured mumps antibody levels by plaque reduction neutralization, by a commercial ELISA (whole-virus antigen), and by ELISAs specific for the mumps nucleoprotein and hemagglutinin. The results indicate that differences in the antibody response to the individual mumps proteins could partially explain the lack of correlation among various serologic tests. Furthermore, the data indicate that some seropositive individuals have low levels of neutralizing antibody. If neutralizing antibody is important for protection, this suggests that previous estimates of immunity based on whole-virus ELISAs may be overstated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.