ArticleClinical and vaccine immunology : CVI2014
Immunoproteomic analysis of antibody in lymphocyte supernatant in patients with typhoid fever in Bangladesh.
Article in Clinical and vaccine immunology : CVI, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 41 citations in OpenAlex.
- Estimating Enteric Fever Seroincidence in Bangladesh Using Rapid Serosurveys.Open forum infectious diseases · 2026Article
- Estimating enteric fever seroincidence in Bangladesh using rapid serosurveys.medRxiv : the preprint server for health sciences · 2026Article
- Review
- Seroepidemiology for Enteric Fever: Emerging Approaches and Opportunities.Open forum infectious diseases · 2023Article
- Seroincidence of Enteric Fever, Juba, South Sudan.Emerging infectious diseases · 2022Article
- Detection of Salmonella Typhi nucleic acid by RT-PCR and anti-HlyE, -CdtB, -PilL, and -Vi IgM by ELISA at sites in Ghana, Madagascar and Ethiopia.BMC infectious diseases · 2022Article
- Estimating typhoid incidence from community-based serosurveys: a multicohort study.The Lancet. Microbe · 2022Article
- An age-stratified serosurvey against purified Salmonella enterica serovar Typhi antigens in the Lao People´s Democratic Republic.PLoS neglected tropical diseases · 2021Article
- Enteric Fever Diagnosis: Current Challenges and Future Directions.Pathogens (Basel, Switzerland) · 2021Review
- Evaluation of a Rapid Point-of-Care Multiplex Immunochromatographic Assay for the Diagnosis of Enteric Fever.mSphere · 2020Article
- Salmonella Typhoid Toxin PltB Subunit and Its Non-typhoidal Salmonella Ortholog Confer Differential Host Adaptation and Virulence.Cell host & microbe · 2020Article
- The role of 9-O-acetylated glycan receptor moieties in the typhoid toxin binding and intoxication.PLoS pathogens · 2020Article
- Plasma Immunoglobulin A Responses Against 2 Salmonella Typhi Antigens Identify Patients With Typhoid Fever.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- The role of systems biology approaches in determining molecular signatures for the development of more effective vaccines.Expert review of vaccines · 2019Review
- Typhoid Fever Diagnosis in Endemic Countries: A Clog in the Wheel of Progress?Medicina (Kaunas, Lithuania) · 2018Review
- Nanomagnetic System for Rapid Diagnosis of Acute Infection.ACS nano · 2017Article
- An evaluation of purified Salmonella Typhi protein antigens for the serological diagnosis of acute typhoid fever.The Journal of infection · 2017Article
- Plasma and Mucosal Immunoglobulin M, Immunoglobulin A, and Immunoglobulin G Responses to the Vibrio cholerae O1 Protein Immunome in Adults With Cholera in Bangladesh.The Journal of infectious diseases · 2017Article
- Development of ELISAs for diagnosis of acute typhoid fever in Nigerian children.PLoS neglected tropical diseases · 2017Article
- Identification of Novel Serodiagnostic Signatures of Typhoid Fever Using aFrontiers in microbiology · 2017Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 4 countries.
Funding
Abstract
We have previously shown that an assay based on detection of anti-Salmonella enterica serotype Typhi antibodies in supernatant of lymphocytes harvested from patients presenting with typhoid fever (antibody in lymphocyte supernatant [ALS] assay) can identify 100% of patients with blood culture-confirmed typhoid fever in Bangladesh. In order to define immunodominant proteins within the S. Typhi membrane preparation used as antigen in these prior studies and to identify potential biomarkers unique to S. Typhi bacteremic patients, we probed microarrays containing 2,724 S. Typhi proteins with ALS collected at the time of clinical presentation from 10 Bangladeshis with acute typhoid fever. We identified 62 immunoreactive antigens when evaluating both the IgG and IgA responses. Immune responses to 10 of these antigens discriminated between individuals with acute typhoid infection and healthy control individuals from areas where typhoid infection is endemic, as well as Bangladeshi patients presenting with fever who were subsequently confirmed to have a nontyphoid illness. Using an ALS enzyme-linked immunosorbent assay (ELISA) format and purified antigen, we then confirmed that immune responses against the antigen with the highest immunoreactivity (hemolysin E [HlyE]) correctly identified individuals with acute typhoid or paratyphoid fever in Dhaka, Bangladesh. These observations suggest that purified antigens could be used with ALS and corresponding acute-phase activated B lymphocytes in diagnostic platforms to identify acutely infected patients, even in areas where enteric fever is endemic.
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