ArticleMolecular biology of the cell2014
ILK modulates epithelial polarity and matrix formation in hair follicles.
Article in Molecular biology of the cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Essential Role of Integrin-Linked Kinase in Keratinocyte Responses to Mechanical Strain.International journal of molecular sciences · 2026Article
- β-arrestin 1 and integrin-linked kinase interact in epidermal keratinocytes and regulate cell motility.Tissue barriers · 2025Article
- Cell-extracellular matrix interactions in the fluidic phase direct the topology and polarity of self-organized epithelial structures.Cell proliferation · 2021Article
- Bioenergetic shift and actin cytoskeleton remodelling as acute vascular adaptive mechanisms to angiotensin II in murine retina and ophthalmic artery.Redox biology · 2020Article
- Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy.Nature communications · 2019Article
- Protective role of integrin-linked kinase against oxidative stress and in maintenance of genomic integrity.Oncotarget · 2018Article
- Scaffolding proteins in the development and maintenance of the epidermal permeability barrier.Tissue barriers · 2017Review
- A reporter mouse model forBiology open · 2017Article
- A proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT/PCP pathway.Molecular neurodegeneration · 2017Article
- Skin-derived stem cells as a source of primordial germ cell- and oocyte-like cells.Cell death & disease · 2016Review
- An ELMO2-RhoG-ILK network modulates microtubule dynamics.Molecular biology of the cell · 2015Article
- PAR-6, but not E-cadherin and β-integrin, is necessary for epithelial polarization in C. elegans.Developmental biology · 2015Article
- Modulation of type II TGF-β receptor degradation by integrin-linked kinase.The Journal of investigative dermatology · 2015Article
- Integrins and epithelial cell polarity.Journal of cell science · 2014Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Hair follicle morphogenesis requires coordination of multiple signals and communication between its epithelial and mesenchymal constituents. Cell adhesion protein platforms, which include integrins and integrin-linked kinase (ILK), are critical for hair follicle formation. However, their precise contribution to this process is poorly understood. We show that in the absence of ILK, the hair follicle matrix lineage fails to develop, likely due to abnormalities in development of apical-basal cell polarity, as well as in laminin-511 and basement membrane assembly at the tip of the hair bud. These defects also result in impaired specification of hair matrix and absence of precortex and inner sheath root cell lineages. The molecular pathways affected in ILK-deficient follicles are similar to those in the absence of epidermal integrin β1 and include Wnt, but not sonic hedgehog, signaling. ILK-deficient hair buds also show abnormalities in the dermal papilla. Addition of exogenous laminin-511 restores morphological and molecular markers associated with hair matrix formation, indicating that ILK regulates hair bud cell polarity and functions upstream from laminin-511 assembly to regulate the developmental progression of hair follicles beyond the germ stage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.