ReviewJournal of physiology and biochemistry2014
n-3 Polyunsaturated fatty acids modulate metabolism of insulin-sensitive tissues: implication for the prevention of type 2 diabetes.
Review in Journal of physiology and biochemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Low-frequency electroacupuncture attenuates insulin resistance in a rat model of diet-induced maternal obesity.Pregnancy (Hoboken, N.J.) · 2026Article
- Antidiabetic Potential of Sea UrchinCurrent issues in molecular biology · 2025Article
- Article
- Adipose Tissue Dysfunctions in Response to an Obesogenic Diet Are Reduced in Mice after Transgenerational Supplementation with Omega 3 Fatty Acids.Metabolites · 2021Article
- Putting ATM to BED: How Adipose Tissue Macrophages Are Affected by Bariatric Surgery, Exercise, and Dietary Fatty Acids.Advances in nutrition (Bethesda, Md.) · 2021Review
- Transgenerational supplementation with eicosapentaenoic acid reduced the metabolic consequences on the whole body and skeletal muscle in mice receiving an obesogenic diet.European journal of nutrition · 2021Article
- Article
- The effects of omega-3 fatty acids supplementation on metabolic status in pregnant women: a systematic review and meta-analysis of randomized controlled trials.Journal of diabetes and metabolic disorders · 2020Review
- Goat's Milk Intake Prevents Obesity, Hepatic Steatosis and Insulin Resistance in Mice Fed A High-Fat Diet by Reducing Inflammatory Markers and Increasing Energy Expenditure and Mitochondrial Content in Skeletal Muscle.International journal of molecular sciences · 2020Article
- Dietary EPA Increases Rat Mortality in Diabetes Mellitus, A Phenomenon Which Is Compensated by Green Tea Extract.Antioxidants (Basel, Switzerland) · 2019Article
- Mechanisms by Which Dietary Fatty Acids Regulate Mitochondrial Structure-Function in Health and Disease.Advances in nutrition (Bethesda, Md.) · 2018Review
- Rapeseed oil fortified with micronutrients can reduce glucose intolerance during a high fat challenge in rats.Nutrition & metabolism · 2018Article
- Article
- Preventive effect of oleate on palmitate-induced insulin resistance in skeletal muscle and its mechanism of action.Journal of physiology and biochemistry · 2017Article
- Gene-Diet Interactions in Type 2 Diabetes: The Chicken and Egg Debate.International journal of molecular sciences · 2017Review
- Omega-3 fatty acids control productions of superoxide and nitrogen oxide and insulin content in INS-1E cells.Journal of physiology and biochemistry · 2016Article
- EPA prevents fat mass expansion and metabolic disturbances in mice fed with a Western diet.Journal of lipid research · 2016Article
- Review
- Maternal Diet Supplementation with n-6/n-3 Essential Fatty Acids in a 1.2 : 1.0 Ratio Attenuates Metabolic Dysfunction in MSG-Induced Obese Mice.International journal of endocrinology · 2016Article
- The Effect of Marine Derived n-3 Fatty Acids on Adipose Tissue Metabolism and Function.Journal of clinical medicine · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is frequently associated with the development of type 2 diabetes which is firstly characterized by a defect in the response of key metabolic tissues to insulin (insulin resistance). The imbalance in fatty composition of the diet, a low-grade inflammatory state have been described to be involved in the initiation or the amplification of the molecular events involved in this process. The concept of a specific nutritional intervention has emerged as a promising tool against metabolic disorders associated with obesity. In this context, many investigations were conducted to evaluate the potential beneficial impacts of n-3 polyunsaturated fatty acids (n-3 PUFA). The aim of the present review was to summarize the current knowledge about the role of docosahexanoic acid (DHA, 22:6n-3) and eicosapentanoic acid (EPA, 20:5n-3) on key metabolic organs. Only studies aiming to understand the mechanism of actions were selected. The analysis of randomized clinical trial about n-3 PUFA was not considered here. The effects of n-3 PUFA were analyzed in the adipose tissue, the liver, skeletal muscle and the pancreas in the context of obesity and lipid oversupply. Furthermore, in line with recent findings about the role of the modulation of gut microbiota in obesity-related disorders, we summarized the recent findings about the possible link between n-3 PUFA and change in microbiota composition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.