ReviewJournal of applied physiology (Bethesda, Md. : 1985)2014
Role of chemoreception in cardiorespiratory acclimatization to, and deacclimatization from, hypoxia.
Review in Journal of applied physiology (Bethesda, Md. : 1985), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 99 citations in OpenAlex.
- Efficacy of Shenqi Pollen Capsules for High-Altitude Deacclimatization Syndrome via Suppression of the Reoxygenation Injury and Inflammatory Response.Journal of immunology research · 2019Trial
- Trial
- Article
- The influence of metaboreflex activation on pulmonary pressure with combined chemoreflex activation in acute and chronic hypoxia.The Journal of physiology · 2026Article
- Sex differences in loop gain measured via superimposed end-expiratory breath holds and inspired steady-state hypoxia.Experimental physiology · 2026Article
- Pulmonary arterial mechanoreceptors mediate sustained sympathoexcitation during high altitude hypoxia in humans.Experimental physiology · 2026Article
- Acute Hypoxia Decreases Maximum Fat Oxidation Rate During Step Incremental Exercise Normalized to Respiratory Compensation Point.European journal of sport science · 2026Article
- Characterizing the protective vasodilatory effects of hypobaric hypoxia on the neurovascular coupling response.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Article
- Cardiorespiratory fitness and effects of ubiquinol during high-altitude acclimatization and deacclimatization: The SCARF trial.iScience · 2025Article
- Comparing integrative ventilatory and renal acid-base acclimatization in lowlanders and Tibetan highlanders during ascent to 4,300 m.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Respiratory Dysfunction and Abnormal Hypoxic Ventilatory Response in Mild to Moderate Parkinson's Disease.Movement disorders clinical practice · 2024Article
- Recovery of ventilatory and metabolic responses to hypoxia in neonatal rats after chronic hypoxia.Respiratory physiology & neurobiology · 2024Article
- Chronic Sustained Hypoxia Leads to Brainstem Tauopathy and Declines the Power of Rhythms in the Ventrolateral Medulla: Shedding Light on a Possible Mechanism.Molecular neurobiology · 2024Article
- Baroreflex and chemoreflex interaction in high-altitude exposure: possible role on exercise performance.Frontiers in physiology · 2024Review
- Influence of chronic hypoxia on the hypoxic ventilatory response of juvenile and adult rats.Respiratory physiology & neurobiology · 2023Article
- Quantifying systemic molecular networks affected during high altitude de-acclimatization.Scientific reports · 2023Article
- Both Hypoxia and Hypobaria Impair Baroreflex Sensitivity but through Different Mechanisms.International journal of sports medicine · 2023Article
- Altitude and Breathing during Sleep in Healthy Persons and Sleep Disordered Patients: A Systematic Review.Sleep science (Sao Paulo, Brazil) · 2023Review
- 7.0T cardiac magnetic resonance imaging of right ventricular function in rats with high-altitude deacclimatization.Annals of translational medicine · 2023Article
- Physiological and performance effects of live high train low altitude training for elite endurance athletes: A narrative review.Current research in physiology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
During sojourn to high altitudes, progressive time-dependent increases occur in ventilation and in sympathetic nerve activity over several days, and these increases persist upon acute restoration of normoxia. We discuss evidence concerning potential mediators of these changes, including the following: 1) correction of alkalinity in cerebrospinal fluid; 2) increased sensitivity of carotid chemoreceptors; and 3) augmented translation of carotid chemoreceptor input (at the level of the central nervous system) into increased respiratory motor output via sensitization of hypoxic sensitive neurons in the central nervous system and/or an interdependence of central chemoreceptor responsiveness on peripheral chemoreceptor sensory input. The pros and cons of chemoreceptor sensitization and cardiorespiratory acclimatization to hypoxia and intermittent hypoxemia are also discussed in terms of their influences on arterial oxygenation, the work of breathing, sympathoexcitation, systemic blood pressure, and exercise performance. We propose that these adaptive processes may have negative implications for the cardiovascular health of patients with sleep apnea and perhaps even for athletes undergoing regimens of "sleep high-train low"!
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.