Evidence map›Paper›PMID 24370741›Full record

ArticleNature genetics2014

Genetic signature of bacterial pathogen adaptation during chronic pulmonary infections.

Steve P Bernier, Matthew L Workentine, Michael G Surette

Abstract readNewsComment
PubMed Publisher
In one paragraph

Article in Nature genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The Flagellar Transcriptional Regulator FtcR ControlsInternational journal of molecular sciences · 2022
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Steve P BernierFarncombe Family Digestive Health Research Institute, Faculty of Health Sciences, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Matthew L WorkentineFarncombe Family Digestive Health Research Institute, Faculty of Health Sciences, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Michael G SuretteFarncombe Family Digestive Health Research Institute, Faculty of Health Sciences, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To establish and maintain chronic infections, many pathogens adapt in response to selective pressures within the host, leaving unique genetic signatures. A new study uses whole-genome and population sequencing approaches to identify evidence of adaptive evolution in Burkholderia dolosa genomes isolated from chronic infections in patients with cystic fibrosis.

Indexed as

Genetic VariationBurkholderiaBurkholderia InfectionsCystic FibrosisHumansMale

Identifiers

PMID24370741

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.