ArticleHernia : the journal of hernias and abdominal wall surgery2014
Comparative analysis of histopathologic responses to implanted porcine biologic meshes.
Article in Hernia : the journal of hernias and abdominal wall surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Techniques for Closing the Abdominal Wall in Intestinal and Multivisceral Transplantation: A Systematic Review.Annals of transplantation · 2022Pooled it
- Collagen Remodeling of Strattice™ Firm in a Nonhuman Primate Model of Abdominal Wall Repair.Bioengineering (Basel, Switzerland) · 2025Article
- The Implant-Induced Foreign Body Response Is Limited by CD13-Dependent Regulation of Ubiquitination of Fusogenic Proteins.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Comparison of mechanical properties and host tissue response to OviTex™ and Strattice™ surgical meshes.Hernia : the journal of hernias and abdominal wall surgery · 2023Article
- Human Primary Dermal Fibroblasts Interacting with 3-Dimensional Matrices for Surgical Application Show Specific Growth and Gene Expression Programs.International journal of molecular sciences · 2021Article
- Evaluation of decellularization protocols for production of porcine small intestine submucosa for use in abdominal wall reconstruction.Hernia : the journal of hernias and abdominal wall surgery · 2020Article
- Extracellular Matrix-Based Biomaterials and Their Influence Upon Cell Behavior.Annals of biomedical engineering · 2020Article
- Comparison of Surgisis, Vypro II and TiMesh in contaminated and clean field.Hernia : the journal of hernias and abdominal wall surgery · 2020Article
- Absorbable Polyglactin vs. Non-Cross-linked Porcine Biological Mesh for the Surgical Treatment of Infected Incisional Hernia.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2020Article
- Biodegradable hyaluronan hydrogel coatings on acellular dermis grafts-A potential strategy to improve biologic graft durability in hernia repair application.Journal of biomedical materials research. Part B, Applied biomaterials · 2019Article
- "Complex abdominal wall" management: evidence-based guidelines of the Italian Consensus Conference.Updates in surgery · 2019Article
- Performance of biological mesh materials in abdominal wall reconstruction: study protocol for a randomised controlled trial.BMJ open · 2019Article
- Postoperative changes after surgical mesh hernia repair: a pitfall in interpretation of 18F-FDG PET-CT.Hernia : the journal of hernias and abdominal wall surgery · 2017Article
- Surgical mesh for ventral incisional hernia repairs: Understanding mesh design.Plastic surgery (Oakville, Ont.) · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesBiologic mesh (BM) prostheses are increasingly utilized for hernia repairs. Modern BMs are not only derived from different tissue sources, but also undergo various proprietary processing steps-factors that likely impact host tissue responses and mesh performance. We aimed to compare histopathologic responses to various BMs after implantation in a mouse model. MATERIALS AND
methodsFive-mm samples of non-crosslinked [Strattice (ST)], and intentionally crosslinked [CollaMend (CM), Permacol (PC)] porcine-derived biologic meshes were implanted subcutaneously in C57BL/6 mice. 1, 4, 8, and 12 weeks post-implantation, meshes were assessed for inflammation, foreign body reaction (FBR), neocellularization, and collagen deposition using H&E and trichrome stains.
resultsAll meshes induced early polymorphonuclear cell infiltration (highest in CM; lowest in ST) that resolved by 4 weeks. ST was associated with extensive macrophage presence at 12 weeks. Foreign body response was not seen in the ST group, but was present abundantly in the CM and PC groups, highest at 8 weeks. New peripheral collagen deposition was seen only in the ST group at 12 weeks. Collagen organization was highest in the ST group as well. Both CM and PC groups were associated with fibrous encapsulation and no evidence of integration or remodeling.
conclusionsInflammation appears to be a common component of integration of all biologic meshes studied. Pronounced inflammatory responses as well as profound FBR likely lead to observed encapsulation and poor host integration of the crosslinked BMs. Overall, ST was associated with the lowest foreign body response and the highest degree of new collagen deposition and organization. These features may be key predictors for improved mesh performance during hernia repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.