ArticleInternational journal of biological macromolecules2014
Immunoregulatory activities of Dendrobium huoshanense polysaccharides in mouse intestine, spleen and liver.
Article in International journal of biological macromolecules, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 54 citations in OpenAlex.
- Optimization of Ultrasonic-Assisted Extraction, Structural Characterization, and Bioactivities of Polysaccharides fromAntioxidants (Basel, Switzerland) · 2026Article
- Diet and Medicinal Herbs as Adjunctive Approaches to Immune Homeostasis in Sjögren's Disease.International journal of molecular sciences · 2026Review
- Emerging neuroprotective mechanisms and therapeutic potential of natural polysaccharides in Alzheimer's disease.Frontiers in aging neuroscience · 2026Review
- Construction of Yeast One-Hybrid Library ofBiomolecules · 2025Article
- Effect of dietary Dendrobium nobile Lindl. On production performance, immune function and caecal microbiota of Chishui black-bone hens.Scientific reports · 2025Article
- Dynamic Double-Networked Hydrogels by Hybridizing PVA and Herbal Polysaccharides: Improved Mechanical Properties and Selective Antibacterial Activity.Gels (Basel, Switzerland) · 2024Article
- Transcriptomic responses to cold stress inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2023Article
- Review
- Qualitative Proteome-Wide Analysis Reveals the Diverse Functions of Lysine Crotonylation inFrontiers in plant science · 2022Article
- Inflammatory response of gut, spleen, and liver in mice induced by orally administeredJournal of oral microbiology · 2022Article
- A Chromosome-Level Genome Assembly of Dendrobium Huoshanense Using Long Reads and Hi-C Data.Genome biology and evolution · 2020Article
- Crude Polysaccharides from Okra Pods (Advances in pharmacological sciences · 2018Article
- A method for extracting high-quality total RNA from plant rich in polysaccharides and polyphenols using Dendrobium huoshanense.PloS one · 2018Article
- Review
- A polysaccharide fromBiotechnology, biotechnological equipment · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
To evaluate the immunomodulating responses in intestine, spleen and liver, 50-200mg/kg of DHP was orally administrated to mice without or with methotrexate. The proliferation of marrow cells, which was performed with the addition of the supernatant of small intestinal lymphocytes isolated from the mice administrated orally with DHP, showed that the intestinal immune response was significantly enhanced in all DHP-treated groups. For the immune response in spleen, all tested doses of DHP remarkably promoted the proliferation of splenic cells and increased the secretion of interferon-γ (IFN-γ). For the immune responses in liver, DHP not only significantly stimulated the proliferation of hepatic cells and the secretion of IFN-γ at all tested doses of DHP, but also significantly elevated the secretion interleukin-4 (IL-4) at the doses of 100 and 200mg/kg. Moreover, DHP could recover methotrexate-injured small intestinal immune function (100 and 200mg/kg) and promoted cell proliferation and IFN-γ production (200mg/kg) in spleen and liver of methotrexate-treated mice. These results suggested that DHP after oral administration possessed immunomodulating effects both in small intestine immune system and in systemic immune system, which were further proved by the mRNA expression of IFN-γ and IL-4.
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Registered trials
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