ArticleDevelopmental biology2014
Midline-derived Shh regulates mesonephric tubule formation through the paraxial mesoderm.
Article in Developmental biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Critical genes in genitourinary embryogenesis are related to the development of adult hydrocele.Scientific reports · 2024Pooled it
- We, the developing rete testis, efferent ducts, and Wolffian duct, all hereby agree that we need to connect.Andrology · 2019Pooled it
- Wnt9b enables androgen action to maintain Wolffian ducts in mice.Molecular human reproduction · 2025Article
- Hedgehog-dependent and hedgehog-independent roles for growth arrest specific 1 in mammalian kidney morphogenesis.Development (Cambridge, England) · 2024Article
- Crucial Roles of the Mesenchymal Androgen Receptor in Wolffian Duct Development.Endocrinology · 2023Article
- Hedgehog signaling regulates Wolffian duct development through the primary cilium†.Biology of reproduction · 2023Article
- Cholesterol Contributes to Male Sex Differentiation Through Its Developmental Role in Androgen Synthesis and Hedgehog Signaling.Endocrinology · 2021Review
- New Insights into Development of Female Reproductive Tract-Hedgehog-Signal Response in Wolffian Tissues Directly Contributes to Uterus Development.International journal of molecular sciences · 2021Article
- Impaired intermediate formation in mouse embryos expressing reduced levels of Tbx6.Genesis (New York, N.Y. : 2000) · 2019Article
- Developmental Contribution of Wnt-signal-responsive Cells to Mouse Reproductive Tract Formation.Acta histochemica et cytochemica · 2017Article
- Sonic hedgehog protein regulates fibroblast growth factor 8 expression in metanephric explant culture from BALB/c mice: Possible mechanisms associated with renal morphogenesis.Molecular medicine reports · 2016Article
- The notochord: structure and functions.Cellular and molecular life sciences : CMLS · 2015Review
- Region-specific regulation of cell proliferation by FGF receptor signaling during the Wolffian duct development.Developmental biology · 2015Article
- Estrogens and development of the rete testis, efferent ductules, epididymis and vas deferens.Differentiation; research in biological diversityArticle
- Understanding normal and abnormal development of the Wolffian/epididymal duct by using transgenic mice.Asian journal of andrologyReview
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
During organogenesis, Sonic hedgehog (Shh) possesses dual functions: Shh emanating from midline structures regulates the positioning of bilateral structures at early stages, whereas organ-specific Shh locally regulates organ morphogenesis at later stages. The mesonephros is a transient embryonic kidney in amniote, whereas it becomes definitive adult kidney in some anamniotes. Thus, elucidating the regulation of mesonephros formation has important implications for our understanding of kidney development and evolution. In Shh knockout (KO) mutant mice, the mesonephros was displaced towards the midline and ectopic mesonephric tubules (MTs) were present in the caudal mesonephros. Mesonephros-specific ablation of Shh in Hoxb7-Cre;Shh(flox/-) and Sall1(CreERT2/+);Shh(flox/-) mice embryos indicated that Shh expressed in the mesonephros was not required for either the development of the mesonephros or the differentiation of the male reproductive tract. Moreover, stage-specific ablation of Shh in Shh(CreERT2/flox) mice showed that notochord- and/or floor plate-derived Shh were essential for the regulation of the number and position of MTs. Lineage analysis of hedgehog (Hh)-responsive cells, and analysis of gene expression in Shh KO embryos suggested that Shh regulated nephrogenic gene expression indirectly, possibly through effects on the paraxial mesoderm. These data demonstrate the essential role of midline-derived Shh in local tissue morphogenesis and differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.