ArticleBMC gastroenterology2013
Endocytoscopic findings of lymphomas of the stomach.
Article in BMC gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Clinical Management of Patients with Gastric MALT Lymphoma: A Gastroenterologist's Point of View.Cancers · 2023Review
- Novel endoscopic approaches using the endocytoscopy for the target biopsy in esophageal eosinophilia.Esophagus : official journal of the Japan Esophageal Society · 2023Article
- Methotrexate-associated proliferative disorder in the lower esophagus extending to the gastroesophageal junction: A case report.DEN open · 2022Article
- Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma in the Gastrointestinal Tract in the Modern Era.Cancers · 2022Review
- Review
- Clinical Efficacy of Endocytoscopy for Gastrointestinal Endoscopy.Clinical endoscopy · 2021Article
- A case of signet ring cell carcinoma and mucosa-associated lymphoid tissue lymphoma of the stomach diagnosed simultaneously via magnifying endoscopy with narrow-band imaging.Clinical journal of gastroenterology · 2021Article
- Localized primary gastric amyloidosis: Three case reports.World journal of clinical cases · 2020Article
- Clinical characteristics of adult T-cell leukemia/lymphoma infiltration in the gastrointestinal tract.BMC gastroenterology · 2020Article
- Endocytoscopy: technology and clinical application in upper gastrointestinal tract.Translational gastroenterology and hepatology · 2020Review
- Diagnosis of Superficial Gastric Lesions Together with Six Gastric Lymphoma Cases via Probe-Based Confocal Laser Endomicroscopy: A Retrospective Observational Study.Gastroenterology research and practice · 2018Article
- Magnifying Endoscopic Features of Follicular Lymphoma Involving the Stomach: A Report of Two Cases.Case reports in gastrointestinal medicine · 2016Article
- Endoscopic detection of the gastric lesions of peripheral T-cell lymphoma.Ecancermedicalscience · 2016Article
- Rare gastrointestinal lymphomas: The endoscopic investigation.World journal of gastrointestinal endoscopy · 2015Review
- Helicobacter pylori-negative gastric mucosa-associated lymphoid tissue lymphomas: A review.World journal of gastroenterology · 2015Review
- Endocytoscopic images of malignant lymphoma located at the terminal ileum.Annals of gastroenterologyArticle
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe gastric lesions of various lymphomas were observed at the cellular level using endocytoscopy.
methodsEndocytoscopy and magnifying endoscopy with narrow band imaging (NBI) were performed in 17 patients with lymphomas of the stomach. The lesions consisted of 7 with low-grade mucosa-associated lymphoid tissue (MALT), 5 with gastric involvement by adult T-cell leukemia/lymphoma (ATLL), 4 with diffuse large B-cell lymphoma (DLBCL), and 1 with peripheral T-cell lymphoma.
resultsOn conventional endoscopy, 9 were classified as having superficial spreading type, 7 were mass-forming type, and 1 was diffuse infiltrating type. Anti-H. pylori treatment was given in the 7 MALT lymphoma cases. NBI magnification endoscopy invariably showed dilatation or ballooning and destruction of gastric pits and elongation and distortion in microvessels. Endocytoscopy showed mucosal aggregation of interstitial cellular elements in almost all gastric lymphoma cases. The nuclear diversity in size and configuration was exclusively seen in gastric lymphomas other than MALT lymphoma, whereas the nuclei of MALT lymphoma cells were regular and small to moderate in size. Inter-glandular infiltration by lymphomatous cell elements was frequently observed in MALT lymphoma and DLBCL, but it was uncommon in peripheral gastric T-cell malignancies. Endocytoscopy could identify the disease-specific histology, the lymphoepithelial origin, as inter-glandular infiltration of cellular components in MALT lymphoma and the possibly related DLBCL cases. Complete regression (CR) was observed in 2 of the 7 MALT lymphoma patients. In the 2 patients with CR who underwent repeat endocytoscopy, the ultra-high magnification abnormalities returned to normal, while they were unchanged in those without tumor regression.
conclusionsOn endocytoscopy, intra-glandular aggregation of cellular components was invariably identified in lymphomas of the stomach. Nuclear regularity in size and configuration may indicate the cytological grade, differentiating the indolent low-grade from aggressive lymphoproliferative diseases. The inter-glandular infiltration seen on endocytoscopy can indicate the lymphoepithelial lesions seen in MALT lymphoma and related DLBCL. Endocytoscopy would be applicable for virtual histopathological diagnosis of different lymphoproliferative disorders and their clinical assessment during ongoing endoscopy.
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