Evidence map›Paper›PMID 24369795›Full record

ReviewThe Journal of allergy and clinical immunology2014

Pharmacogenetics: implications of race and ethnicity on defining genetic profiles for personalized medicine.

Victor E Ortega, Deborah A Meyers

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of allergy and clinical immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed, 12 pooled it
19.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 12 syntheses or guidelines pooled it, 233 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. ADRB2 haplotypes and asthma exacerbations in children and young adults: An individual participant data meta-analysis.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021
    Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Trial
  14. Trial
  15. Trial
  16. Genome-wide association study of inhaled corticosteroid response in admixed children with asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019
    Trial
  17. Trial
  18. Observational
  19. Article
  20. Article

58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Victor E OrtegaCenter for Genomics and Personalized Medicine, Wake Forest School of Medicine, Winston-Salem, NC.
Deborah A MeyersCenter for Genomics and Personalized Medicine, Wake Forest School of Medicine, Winston-Salem, NC. Electronic address: dmeyers@wakehealth.edu.
Wake Forest University · US

Funding

Atlantic Coast Consortium for Asthma (ACC-A) AsthmaNet Clinical SiteU10HL098103 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI FITZPATRICK, ANNE MENTRO, PETERS, STEPHEN P · 2009 to 2015
$4.5M
Longitudinal Phenomics and Genetics of Severe AsthmaU10HL109164 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BLEECKER, EUGENE ROLAND, MEYERS, DEBORAH A. · 2011 to 2016
$3.8M
Genetics of lung function and asthma severity in African AmericansR01NR013700 · NINR · EMORY UNIVERSITY · PI FITZPATRICK, ANNE MENTRO, MEYERS, DEBORAH A. · 2013 to 2017
$2.4M
NHLBI NIH HHS U10 HL098103NHLBI NIH HHS U10 HL109164NINR NIH HHS R01 NR013700
6 · The paper itself

Abstract

Pharmacogenetics is being used to develop personalized therapies specific to subjects from different ethnic or racial groups. To date, pharmacogenetic studies have been primarily performed in trial cohorts consisting of non-Hispanic white subjects of European descent. A "bottleneck" or collapse of genetic diversity associated with the first human colonization of Europe during the Upper Paleolithic period, followed by the recent mixing of African, European, and Native American ancestries, has resulted in different ethnic groups with varying degrees of genetic diversity. Differences in genetic ancestry might introduce genetic variation, which has the potential to alter the therapeutic efficacy of commonly used asthma therapies, such as β2-adrenergic receptor agonists (β-agonists). Pharmacogenetic studies of admixed ethnic groups have been limited to small candidate gene association studies, of which the best example is the gene coding for the receptor target of β-agonist therapy, the β2-adrenergic receptor (ADRB2). Large consortium-based sequencing studies are using next-generation whole-genome sequencing to provide a diverse genome map of different admixed populations, which can be used for future pharmacogenetic studies. These studies will include candidate gene studies, genome-wide association studies, and whole-genome admixture-based approaches that account for ancestral genetic structure, complex haplotypes, gene-gene interactions, and rare variants to detect and replicate novel pharmacogenetic loci.

Indexed as

Adrenergic beta-AgonistsAdultAsthmaGenome-Wide Association StudyGenotypeHispanic or LatinoHumansPharmacogeneticsPolymorphism, Single NucleotidePrecision MedicineReceptors, Adrenergic, beta-2White PeopleAdrenergic beta-AgonistsReceptors, Adrenergic, beta-2admixture mappingADRB1ADRB2AsthmaBADGERBARGEBest Add-on Therapy Giving Effective Response TrialBeta Agonist Response by Genotype TrialCAAPAConsortium on Asthma among African-ancestry Populations in the Americasethnic groupGALAgenesGenetics of Asthma in Latino AmericansGenome-wide association studyGLCCl1Glucocorticoid-induced transcript 1 geneG protein receptor kinase 5GRK5GWASICSInhaled corticosteroidLABALARGELong-acting Beta Agonist Response by GenotypeLong-acting β-agonistNational Heart, Lung, and Blood InstituteNational Institutes of HealthNHLBINIHPeak expiratory flow ratePEFRpharmacogeneticsresponse heterogeneitySABASalmeterol Multicenter Asthma Research TrialShort-acting β-agonistsingle nucleotide polymorphismSingle nucleotide polymorphismSMARTSNPSPATS2LSpermatogenesis-associated, serine-rich 2-like geneβ(1)-Adrenergic receptorβ(2)-Adrenergic receptor

Identifiers

PMID24369795
PMCPMC3933289
OpenAlexW1979046034

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.