ArticleBMC veterinary research2013
Novel bacteriophage therapy for controlling metallo-beta-lactamase producing Pseudomonas aeruginosa infection in catfish.
Article in BMC veterinary research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 60 citations in OpenAlex.
- Characterization of Giant Myoviridae With Therapeutic Potential Against Grouper Pathogen,International journal of microbiology · 2026Article
- Genomic variation inMicrobiology spectrum · 2025Article
- Bacteriophage Therapy in Freshwater and Saltwater Aquaculture Species.Microorganisms · 2025Review
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- Taxifolin Inhibits WSSV Infection and Transmission by Increasing the Innate Immune Response inViruses · 2022Article
- In Vivo Bacteriophages' Application for the Prevention and Therapy of Aquaculture Animals-Chosen Aspects.Animals : an open access journal from MDPI · 2022Review
- Delivering the pain: an overview of the type III secretion system with special consideration for aquatic pathogens.Veterinary research · 2021Review
- Isolation and characterization of a lytic bacteriophage against Pseudomonas aeruginosa.Scientific reports · 2021Article
- Phage Therapy as a Focused Management Strategy in Aquaculture.International journal of molecular sciences · 2021Review
- Phages in Food Industry Biocontrol and Bioremediation.Antibiotics (Basel, Switzerland) · 2021Review
- Characterization of vB_VpaP_MGD2, a newly isolated bacteriophage with biocontrol potential against multidrug-resistant Vibrio parahaemolyticus.Archives of virology · 2021Article
- Evaluation of Phage Therapy for Pulmonary Infection of Mouse by Liquid Aerosol-ExposureInfection and drug resistance · 2021Article
- inPhocus: A Local Perspective on Phage-Based Biocontrol in Agriculture and Aquaculture in India.PHAGE (New Rochelle, N.Y.) · 2020Article
- Growing Trend of Fighting Infections in Aquaculture Environment-Opportunities and Challenges of Phage Therapy.Antibiotics (Basel, Switzerland) · 2020Review
- Complete genome sequences of Aeromonas and Pseudomonas phages as a supportive tool for development of antibacterial treatment in aquaculture.Virology journal · 2019Article
- Article
- EMA and EFSA Joint Scientific Opinion on measures to reduce the need to use antimicrobial agents in animal husbandry in the European Union, and the resulting impacts on food safety (RONAFA).EFSA journal. European Food Safety Authority · 2017Article
- Poly-γ-Glutamic Acid: Biodegradable Polymer for Potential Protection of Beneficial Viruses.Materials (Basel, Switzerland) · 2016Article
- Phage Therapy: a Step Forward in the Treatment of Pseudomonas aeruginosa Infections.Journal of virology · 2015Review
- Antibiotic adjuvants: diverse strategies for controlling drug-resistant pathogens.Chemical biology & drug design · 2015Article
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe bacteriophage therapy is an effective antimicrobial approach with potentially important applications in medicine and biotechnology which can be seen as an additional string in the bow. Emerging drug resistant bacteria in aquaculture industry due to unrestricted use of antibiotics warrants more sustainable and environmental friendly strategies for controlling fish infections.The isolated bacteria from fish lesions was characterised based on isolation on selective and differential medium like Pseudomonas agar, gram staining, biochemical tests and 16SrRNA sequencing. The metallo-beta-lactamase (MBL) producing bacterial isolate was evaluated using Imipenem - Ethylenediaminetetraacetic acid (EDTA) disk method. The specific bacteriophage was isolated and concentrated using coal bed developed in our lab at CSIR-NEERI. The isolated and enriched bacteriophage was characterised by nucleotide sequencing and electron microscopy. The phage therapy was applied for treating ulcerative lesion in fish.
resultsThe pathogenic bacterium responsible for causing ulcerative lesions in catfish species (Clarias gariepinus) was identified as Pseudomonas aeruginosa. One out of twenty P. aeruginosa isolate showing multi drug resistance (MDR) was incidentally found to be MBL producing as determined by Imipenem-EDTA disk method. The phage therapy effectively cured the ulcerative lesions of the infected fish in 8-10 days of treatment, with a sevenfold reduction of the lesion with untreated infection control.
conclusionBacteriophage therapy can have potential applications soon as an alternative or as a complement to antibiotic treatment in the aquaculture. We present bacteriophage therapy as a treatment method for controlling MDR P. aeruginosa infection in C. gariepinus. To the best of our knowledge this is a first report of application of phage therapy against MBL producing P. aeruginosa isolated from aquatic ecosystem.
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